Publication Name	World Journal of Gastroenterology
Manuscript ID	119558
Country	China

Category	Biotechnology & Applied Microbiology
Manuscript Type	Opinion Review
Article Title	Gut microbiota-fatty acid oxidation interplay in aging: Mechanisms, controversies, and translational perspectives
Manuscript Source	Unsolicited Manuscript
All Author List	Chih-Yuan Ko
Funding Agency and Grant Number
Corresponding Author	Chih-Yuan Ko, Affiliate Associate Professor, PhD, Research Assistant Professor, Department of Clinical Nutrition, Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshanbei Road, Licheng District, Quanzhou 362000, Fujian Province, China. yuanmomoko@gmail.com
Key Words	Aging; Gut microbiota; Fatty acid oxidation; Mitochondrial metabolism; Short-chain fatty acids; Bile acids; Metabolic senescence; Healthy aging
Core Tip	Gut microbiota remodeling during aging may influence fatty acid oxidation through microbial metabolites and host signaling pathways. This opinion review highlights fatty acid oxidation as a context-dependent metabolic node linking microbiota changes to aging phenotypes, while emphasizing unresolved causality, tissue specificity, and the need for integrated metabolic validation.
Citation	Ko CY. Gut microbiota-fatty acid oxidation interplay in aging: Mechanisms, controversies, and translational perspectives. World J Gastroenterol 2026; In press

Received	2026-02-07 04:09
Peer-Review Started	2026-02-07 04:14
First Decision by Editorial Office Director	2026-02-26 08:17
Return for Revision	2026-02-26 08:17
Revised	2026-03-10 16:38
Publication Fee Transferred
Second Decision by Editor	2026-05-18 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 06:58
Articles in Press	2026-05-18 06:58
Edit the Manuscript by Language Editor	2026-05-19 03:37
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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