Publication Name	World Journal of Gastroenterology
Manuscript ID	119570
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Depleting apolipoprotein C3 alleviates acute pancreatitis in hamsters but not in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Gong-Lie Chen, Kai-Kai Lu, Wen-Xi Zhang, Ping-Ping Lai, Yi-Tong Xu, Yu-Fei Han, Zi-Hao Zhou, Wei Huang, Yu-Hui Wang, Yue Zhang and Xun-De Xian
Funding Agency and Grant Number	Funding Agency Grant Number the Jiangxi Provincial Natural Science Foundation, China 20212BAB216022 National Natural Science Foundation of China 82270479 and 82501040 China Postdoctoral Science Foundation 2025M771442
Corresponding Author	Xun-De Xian, PhD, Professor, Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, No. 38 Xueyuan Road, Huayuanlu Subdistrict, Haidian District, Beijing 100191, China. xianxunde@bjmu.edu.cn
Key Words	Acute pancreatitis; Apolipoprotein C3; Hypertriglyceridemia; Hamster model; Inflammation
Core Tip	Hypertriglyceridemia (HTG) has been shown to cause acute pancreatitis (AP), but the mechanisms remain unclear. This study identified apolipoprotein C3 (ApoC3) as a key player in AP pathogenesis. In three hamster AP models, ApoC3 deficiency significantly reduced pancreatic injury by improving lipid metabolism, suppressing inflammatory cytokine production, and limiting immune cell infiltration. In contrast, ApoC3 deficiency showed no protective effect in mice, underscoring the importance of appropriate model selection. Our findings establish ApoC3 as a critical molecular bridge between dyslipidemia and pancreatic inflammation, highlighting its potential as a novel therapeutic target for HTG-related AP.
Citation	Chen GL, Lu KK, Zhang WX, Lai PP, Xu YT, Han YF, Zhou ZH, Huang W, Wang YH, Zhang Y, Xian XD. Depleting apolipoprotein C3 alleviates acute pancreatitis in hamsters but not in mice. World J Gastroenterol 2026; In press

Received	2026-02-02 03:22
Peer-Review Started	2026-02-02 03:25
First Decision by Editorial Office Director	2026-03-27 12:36
Return for Revision	2026-03-27 12:36
Revised	2026-04-08 16:23
Publication Fee Transferred	2026-04-09 14:37
Second Decision by Editor	2026-05-18 02:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 08:12
Articles in Press	2026-05-18 08:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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