Publication Name	World Journal of Gastroenterology
Manuscript ID	119588
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	CRAPT-M: An effective prognostic predictor for hepatocellular carcinoma patients treated with locoregional-bevacizumab-immunotherapy
Manuscript Source	Unsolicited Manuscript
All Author List	Ze-Hao Zheng, Rui Xiao, Na Liu, Ben-Yi He, Wei Yu, Zhong-Shi Wu, Min-Shan Chen, Jie Mei, Dan-Dan Hu and Rong-Ping Guo
Funding Agency and Grant Number	Funding Agency Grant Number the National Science and Technology Major Project of China 2024ZD0520402 Science and Technology Planning Project of Guangzhou 2023A03J0601
Corresponding Author	Rong-Ping Guo, Department of Hepatobiliary Oncology,, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, No. 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, Peoples Republic of China., Guangzhou 510060, Guangdong Province, China. guorp@sysucc.org.cn
Key Words	Hepatocellular carcinoma; Bevacizumab; Checkpoint inhibitors; Hepatic arterial infusion chemotherapy; C reactive protein; Overall survival
Core Tip	This study validated the prognostic value of the CRAPT-M model in patients with hepatocellular carcinoma receiving locoregional-bevacizumab-immunotherapy. The model effectively stratified overall survival and progression-free survival not only in the locoregional plus atezolizumab plus bevacizumab group but also in the locoregional plus sintilimab plus bevacizumab group. In addition, we developed a Simple-CRAPT-M model based on the number of risk factors, which may provide a more convenient tool for rapid risk stratification in clinical practice.
Citation	Zheng ZH, Xiao R, Liu N, He BY, Yu W, Wu ZS, Chen MS, Mei J, Hu DD, Guo RP. CRAPT-M: An effective prognostic predictor for hepatocellular carcinoma patients treated with locoregional-bevacizumab-immunotherapy. World J Gastroenterol 2026; In press

Received	2026-02-02 03:05
Peer-Review Started	2026-02-02 03:05
First Decision by Editorial Office Director	2026-02-06 10:49
Return for Revision	2026-02-06 10:49
Revised	2026-02-19 11:08
Publication Fee Transferred	2026-02-24 05:53
Second Decision by Editor	2026-03-13 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-13 06:35
Articles in Press	2026-03-13 06:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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