Publication Name	World Journal of Gastroenterology
Manuscript ID	119605
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Cladosporium cladosporioides ameliorates visceral hypersensitivity in irritable bowel syndrome-like mice by inhibiting dectin-1 signaling and mast cell activation
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Lin Guo, Shang-Qing Zhang, Hao-Nan Zheng, Yan Chi and Hua-Hong Wang
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Beijing Municipality 7212110 Peking University First Hospital Youth Clinical Research Special Fund 2018CR06 Peking University First Hospital Interdisciplinary Clinical Research Special Fund 2019CR42
Corresponding Author	Yan Chi, Associate Professor, Chief Physician, MD, Department of Gastroenterology, Peking University First Hospital, No. 8 Xishiku Road, Xicheng District, Beijing 100034, China. chiyan@bjmu.edu.cn
Key Words	Cladosporium; Mycobiota; Mast cell; Dectin-1; Visceral hypersensitivity
Core Tip	Gut mycobiota are linked to visceral hypersensitivity (VH) in irritable bowel syndrome (IBS); however, the specific role of fungi in IBS remains unexplored. This study explored the role of the gut mycobiota in VH associated with diarrhea-predominant IBS. We identified Cladosporium as a key fungal genus enriched in diarrhea-predominant IBS patients and demonstrated that Cladosporium cladosporioides (C. cladosporioides) alleviates IBS-VH in mice. Mechanistically, C. cladosporioides reduces inflammatory cytokine levels, inhibits mast cell activation, and downregulates dectin-1/nuclear factor kappa B signaling. These findings suggest C. cladosporioides as a potential therapeutic probiotic for IBS-VH, highlighting the role of this gut fungus in modulating IBS pathogenesis.
Citation	Guo CL, Zhang SQ, Zheng HN, Chi Y, Wang HH. Cladosporium cladosporioides ameliorates visceral hypersensitivity in irritable bowel syndrome-like mice by inhibiting dectin-1 signaling and mast cell activation. World J Gastroenterol 2026; In press

Received	2026-02-02 03:04
Peer-Review Started	2026-02-02 03:05
First Decision by Editorial Office Director	2026-02-26 08:19
Return for Revision	2026-02-26 08:19
Revised	2026-03-17 15:57
Publication Fee Transferred	2026-03-22 06:13
Second Decision by Editor	2026-04-24 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-24 10:59
Articles in Press	2026-04-24 10:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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