Publication Name	World Journal of Clinical Oncology
Manuscript ID	119607
Country	China

Category	Oncology
Manuscript Type	Prospective Study
Article Title	Clinical study of Xianjun formula combined with standard western therapy in metastatic colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Lin-Feng Wang, Yu-Xing Sun, Jiang-Yu Bian and Tong Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Xiyuan Hospital of China Academy of Chinese Medical Sciences No．XYZX0201-22
Corresponding Author	Tong Zhang, Associate Chief Physician, PhD, Department of Oncology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1, Xiyuan Playground, Haidian District, Beijing, China Academy of Chinese Medical Sciences Xiyuan Hospital, Beijing 100091, China. ashtray7654@126.com
Key Words	Xianjun Formula; Metastatic colorectal cancer; Microsatellite stable; Late-line therapy; Overall survival; Integrative medicine
Core Tip	Most metastatic colorectal cancer (mCRC) patients are microsatellite stable (MSS) and derive limited benefit from immune checkpoint inhibitor-based therapies, especially in late-line settings. This prospective, multicenter, single-arm clinical trial explores the feasibility and survival benefit of integrating Xianjun Formula, a traditional Chinese medicine compound, with standard Western therapies in refractory MSS mCRC. By targeting the tumor immune microenvironment, this study aims to provide preliminary clinical evidence supporting an integrative therapeutic strategy for patients lacking effective treatment options.
Citation	Wang LF, Sun YX, Bian JY, Zhang T. Clinical study of Xianjun formula combined with standard western therapy in metastatic colorectal cancer. World J Clin Oncol 2026; In press

Received	2026-02-02 02:48
Peer-Review Started	2026-02-02 02:48
First Decision by Editorial Office Director	2026-02-27 08:51
Return for Revision	2026-02-27 08:51
Revised	2026-03-11 20:28
Publication Fee Transferred	2026-04-06 14:48
Second Decision by Editor	2026-05-11 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-11 09:47
Articles in Press	2026-05-11 09:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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