Publication Name	World Journal of Neurology
Manuscript ID	119653
Country	China

Category	Clinical Neurology
Manuscript Type	Review
Article Title	Vascular risk factors and cognitive decline: An integrated perspective from epidemiology to precision intervention
Manuscript Source	Invited Manuscript
All Author List	Bin Jiang
Funding Agency and Grant Number
Corresponding Author	Bin Jiang, MD, Professor, Senior Research Fellow, Department of Neuroepidemiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Road West, Fengtai District, Beijing 100070, China. bjyjiang@hotmail.com
Key Words	Vascular risk factors; Cognitive decline; Vascular cognitive impairment; Cerebral small vessel disease; Mechanisms; Management; Review
Core Tip	Vascular pathology is a core driver of cognitive decline (often coexisting with Alzheimer’s disease pathology). Midlife (40-65 years) is the critical prevention window. Key mechanisms include cerebral small vessel disease, blood-brain barrier disruption, neurovascular unit dysfunction, and neuroinflammation. Hypertension (including blood pressure variability) is the primary intervention target. Lifestyle interventions (e.g., FINGER model) are the most effective broad prevention strategy. Current challenges include diagnostic difficulties and insufficient personalized interventions. The core message is that maintaining vascular health maintains brain health.
Citation	Jiang B. Vascular risk factors and cognitive decline: An integrated perspective from epidemiology to precision intervention. World J Neurol 2026; In press

Received	2026-02-03 01:28
Peer-Review Started	2026-02-03 01:28
First Decision by Editorial Office Director	2026-02-27 09:01
Return for Revision	2026-02-27 09:01
Revised	2026-03-06 07:59
Publication Fee Transferred
Second Decision by Editor	2026-05-18 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 09:33
Articles in Press	2026-05-18 09:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-6212 (online)
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