Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119682
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Association between physical activity and early-stage gastric cancer: A cross-sectional study of the Wuwei cohort
Manuscript Source	Unsolicited Manuscript
All Author List	Hao Yuan, Qin Sun, Zhe Wang, Xi-Dong Fang, Jing Yang, Zhi-Yu Wu, Xin-Hong Cheng, Ya Zheng and Yong-Ning Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82160498 The Foundation of The First Hospital of Lanzhou University, China ldyyyn2019-28 The Medical Innovation and Development Project of Lanzhou University lzuyxcx-2022-41 Gansu Province Higher Education Project for Teaching Achievement Cultivation 202314-16 Natural Science Foundation of Gansu Province 23JRRA0939
Corresponding Author	Yong-Ning Zhou, Department of Gastroenterology, The First Hospital of Lanzhou University, No. 1 West Donggang Road, Lanzhou 730000, Gansu Province, China. zhouyn@lzu.edu.cn
Key Words	Early gastric cancer; Stomach neoplasms; Physical activity; Exercise; Risk factors
Core Tip	This cross-sectional analysis of 1829 adults from a high-risk Chinese population demonstrates that moderate physical activity (PA), assessed by the International PA Questionnaire-Short Form, is associated with lower odds of high-grade dysplasia and early gastric cancer. A significant dose-response trend and a non-linear inverse association are observed, with the lowest risk at intermediate activity levels. The inverse association is more pronounced among Helicobacter pylori-positive individuals and patients with cardia lesions. These findings suggest that moderate PA may play a role in early gastric carcinogenesis and prevention strategies.
Citation	Yuan H, Sun Q, Wang Z, Fang XD, Yang J, Wu ZY, Cheng XH, Zheng Y, Zhou YN. Association between physical activity and early-stage gastric cancer: A cross-sectional study of the Wuwei cohort. World J Gastrointest Oncol 2026; In press

Received	2026-02-04 01:54
Peer-Review Started	2026-02-04 01:55
First Decision by Editorial Office Director	2026-02-14 07:56
Return for Revision	2026-02-14 09:42
Revised	2026-02-27 11:12
Publication Fee Transferred	2026-02-28 11:53
Second Decision by Editor	2026-04-03 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-03 06:28
Articles in Press	2026-04-03 06:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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