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Publication Name World Journal of Gastroenterology
Manuscript ID 119684
Country China
Category Biochemistry & Molecular Biology
Manuscript Type Opinion Review
Article Title Interleukin-33/suppression of tumorigenicity 2 signaling in gastric injury: From mechanistic validation to spatiotemporal precision
Manuscript Source Invited Manuscript
All Author List Wan-Ting Qi, Xiao-hua Jia, Kai-Lin Xue, Jing-Wen Wang and Lei Liang
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China No. 62371010
Corresponding Author Lei Liang, MD, PhD, Professor, Department of Ultrasound, Aerospace Center Hospital, No. 15 Yuquan Street, Haidian District, Beijing 100049, China. lianglei_csk@126.com
Key Words Interleukin-33; Suppression of tumorigenicity 2; Molecular imaging; Gastric injury; Molecular target screening
Core Tip Current studies have established the involvement of interleukin (IL)-33/suppression of tumorigenicity 2 signaling in gastric injury, but most evidence remains derived from static endpoint analyses. We propose that future progress depends on defining when, where, and in which cell populations this pathway shifts from injury-promoting to repair-associated functions. By integrating phase-specific biology with molecular imaging of IL-33, tumor necrosis factor alpha, cysteine-aspartic protease-3, and related targets, a spatiotemporal framework may be developed to identify therapeutic windows and support precision intervention in gastric mucosal injury.
Citation Qi WT, Jia XH, Xue KL, Wang JW, Liang L. Interleukin-33/suppression of tumorigenicity 2 signaling in gastric injury: From mechanistic validation to spatiotemporal precision. World J Gastroenterol 2026; In press
Received
2026-02-12 01:18
Peer-Review Started
2026-02-12 01:18
First Decision by Editorial Office Director
2026-02-27 10:18
Return for Revision
2026-02-27 10:18
Revised
2026-04-14 08:45
Publication Fee Transferred
Second Decision by Editor
2026-05-12 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-12 09:05
Articles in Press
2026-05-12 09:05
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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