Publication Name	World Journal of Diabetes
Manuscript ID	119692
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Diabetic osteoporosis: Focus on ferroptosis as a key player and future prospect in traditional Chinese medicine
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Ran Geng and Yang Liu
Funding Agency and Grant Number
Corresponding Author	Yang Liu, Chief Physician, Department of Endocrinology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huanggu District, Shenyang 110032, Liaoning Province, China. liuyang_linda@163.com
Key Words	Diabetic osteoporosis; Ferroptosis; Bone metabolism; Traditional Chinese medicine; Treatment methods
Core Tip	Diabetic osteoporosis (DOP) poses high disability and fracture risks, with high-glucose-induced bone cell ferroptosis (driven by iron overload, lipid peroxidation and system Xc⁻/glutathione/glutathione peroxidase 4 imbalance) as its core pathogenesis. Western medicine cannot synergistically improve glucose and bone metabolism and has side effects. This minireview focuses on the high-glucose-bone cell ferroptosis-DOP axis, clarifies ferroptosis mechanisms in key bone cells, and describes how traditional Chinese medicine (TCM) targets ferroptosis via multiple pathways to treat DOP. We bridge TCM theory and the molecular mechanisms of ferroptosis, and discuss TCM-based DOP research directions and clinical translation.
Citation	Geng XR, Liu Y. Diabetic osteoporosis: Focus on ferroptosis as a key player and future prospect in traditional Chinese medicine. World J Diabetes 2026; In press

Received	2026-02-03 00:26
Peer-Review Started	2026-02-06 09:38
First Decision by Editorial Office Director	2026-03-12 08:16
Return for Revision	2026-03-12 08:16
Revised	2026-03-23 12:23
Publication Fee Transferred	2026-05-19 05:51
Second Decision by Editor	2026-05-18 02:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 06:44
Articles in Press	2026-05-18 06:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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