Publication Name	World Journal of Diabetes
Manuscript ID	119780
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Assessment of the role of general control nonderepressible 2 in gestational diabetes mellitus progression and the underlying mechanisms
Manuscript Source	Unsolicited Manuscript
All Author List	Wan Li, Ya-Ru Wang and Shu-Li Wang
Funding Agency and Grant Number	Funding Agency Grant Number Shenzhen Nanshan District Health Science and Technology Program Project NS2023102
Corresponding Author	Shu-Li Wang, MD, Research Fellow, Gynecology and Obstetrics, Hua Zhong University of Science and Technology Union Shenzhen Hospital (Nanshan District People's Hospital), No.89 Taoyuan Road, Nantou Street, Shenzhen 518000, Guangdong Province, China. sznsnancy@163.com
Key Words	Endoplasmic reticulum stress; General control nonderepressible 2; Gestational diabetes mellitus; Mitochondria; Glucose and lipid metabolism
Core Tip	General control nonderepressible 2 is an important regulator of cellular stress responses, but its role in gestational diabetes mellitus remains unclear. This study demonstrates that it contributes to metabolic dysfunction and placental injury by modulating endoplasmic reticulum stress-associated mitochondrial dysfunction. Silencing this molecule alleviates oxidative stress and apoptosis while improving glucose and lipid metabolism. These findings suggest a potential mechanistic link between cellular stress and placental dysfunction and highlight a possible therapeutic target.
Citation	Li W, Wang YR, Wang SL. Assessment of the role of general control nonderepressible 2 in gestational diabetes mellitus progression and the underlying mechanisms. World J Diabetes 2026; In press

Received	2026-02-06 00:32
Peer-Review Started	2026-02-12 05:32
First Decision by Editorial Office Director	2026-03-04 08:57
Return for Revision	2026-03-04 08:57
Revised	2026-03-31 03:15
Publication Fee Transferred
Second Decision by Editor	2026-05-06 03:21
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-15 07:26
Articles in Press	2026-05-15 07:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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