Publication Name	World Journal of Meta-Analysis
Manuscript ID	119849
Country	Lebanon

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Glucagon-like peptide-1-based incretin agonists in obesity-related heart failure with preserved ejection fraction: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Ehab Al Mashtoub, Ali Hteit, Anthony Bedran, Janette Al Banna, Charbel El Hachem, Nazih Obeid, Mostafa Msheik, Mohamad Tlais and Razan Abdulaal
Funding Agency and Grant Number
Corresponding Author	Mohamad Tlais, MD, Cardiology, University of Balamand, Hazmieh, Beirut 1100, Beyrouth, Lebanon. mmtlaiss22@gmail.com
Key Words	Heart failure with preserved ejection fraction; Obesity-related heart failure with preserved ejection fraction; Glucagon-like peptide-1 receptor agonists; Dual GIP/GLP-1 receptor agonist; Incretin agonists; Semaglutide; Tirzepatide; Weight loss; Meta-analysis; Systematic review
Core Tip	Glucagon-like peptide-1 (GLP)-1-based incretin agonists, including semaglutide and the dual GIP/GLP-1 receptor agonist tirzepatide, produce consistent and clinically meaningful improvements in symptoms, functional capacity, and body weight in patients with obesity-related heart failure with preserved ejection fraction. Tirzepatide additionally reduced the composite of cardiovascular death or worsening heart failure events, establishing weight-centric pharmacotherapy as a promising disease-modifying strategy for this high-risk and previously treatment-resistant phenotype.
Citation	Al Mashtoub E, Hteit A, Bedran A, Al Banna J, El Hachem C, Obeid N, Msheik M, Tlais M, Abdulaal R. Glucagon-like peptide-1-based incretin agonists in obesity-related heart failure with preserved ejection fraction: A systematic review and meta-analysis. World J Meta-Anal 2026; In press

Received	2026-02-07 03:17
Peer-Review Started	2026-02-07 03:17
First Decision by Editorial Office Director	2026-02-28 06:50
Return for Revision	2026-02-28 22:02
Revised	2026-03-08 20:40
Publication Fee Transferred
Second Decision by Editor	2026-03-19 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-19 09:51
Articles in Press	2026-03-19 09:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2308-3840 (online)
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