Publication Name	World Journal of Stem Cells
Manuscript ID	119892
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Regulatory T cell-derived exosomes regulate β-catenin expression to promote the stem cell-like properties of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Jun Tu, Yun-Qi Liu, Hong-Yang Cai, Yan-Yan Pan and Chang Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82303572 Department of Science & Technology of Liaoning Province 2024-MS-285 Hospital Initiated Project of “Liaoning Province Key Specialty” 2023SZ015
Corresponding Author	Chang Liu, Affiliate Associate Professor, PhD, Central Laboratory, Central Hospital of Dalian University of Technology, No. 826 Southwest Road, Dalian 116033, Liaoning Province, China. liuch2024@dlut.edu.cn
Key Words	Regulatory T cell; Exosome; Cancer stem cell; Tumor-initiating cell; Hepatocellular carcinoma
Core Tip	In our previous study, we demonstrated that regulatory T (Treg) cells increase the population of tumor-initiating cells in hepatocellular carcinoma by suppressing forkhead box P3 and enhancing β-catenin expression. However, it remained unclear whether Treg cells exert these effects through exosomes and which specific components within Treg-derived exosomes are responsible. In this study, we revealed that exosomal long non-coding RNA Flicr, derived from Treg cells, suppresses forkhead box P3 and glycogen synthase kinase-3 beta expression and activates the Wnt/β-catenin signaling pathway, thereby promoting stem cell-like properties in hepatocellular carcinoma cells.
Citation	Tu YJ, Liu YQ, Cai HY, Pan YY, Liu C. Regulatory T cell-derived exosomes regulate β-catenin expression to promote the stem cell-like properties of hepatocellular carcinoma. World J Stem Cells 2026; In press

Received	2026-02-10 02:51
Peer-Review Started	2026-02-10 02:53
First Decision by Editorial Office Director	2026-02-14 07:59
Return for Revision	2026-02-15 07:01
Revised	2026-02-27 08:20
Publication Fee Transferred	2026-03-02 00:09
Second Decision by Editor	2026-03-27 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-03 07:02
Articles in Press	2026-04-03 07:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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