| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
AKT-eNOS-NO pathway mediates spontaneous portosystemic shunts and therapeutic efficacy of SC79 in cirrhosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qiao Ke, Zhi-Ting Guo, Jian He, Xin-Hui Huang, Xiao-Juan Lei, Qiu-Yu Zhuang, Yang Zhou, Ling Li, Ying-Chao Wang, Jing-Feng Liu and Wu-Hua Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Joint Funds for the Innovation of Science and Technology of Fujian Province, China |
2021Y9033 |
| the Key Clinical Specialty Discipline Construction Program of Fuzhou, Fujian Province, China |
|
| the Natural Science Foundation of Fujian Province, China |
2023J011463 |
|
| Corresponding Author |
Wu-Hua Guo, MD, PhD, Professor, Department of Interventional Radiology, Mengchao Hepatobiliary Hospital of Fujian Medical University, No. 66, Jintang Road, Fuzhou 350025, Fujian, China., Fuzhou 350025, Fujian Province, China. guowuhua@aliyun.com |
| Key Words |
Liver cirrhosis; Portal hypertension; Portosystemic shunt; Spontaneous; Prognosis; Proto-oncogene proteins c-AKT |
| Core Tip |
Spontaneous portosystemic shunts (SPSS) are strongly associated with adverse outcomes in hepatitis B virus-related cirrhosis, including more frequent decompensation and higher mortality. By integrating multicenter clinical data with proteomic, metabolomic, and animal studies, this work identifies dysregulation of the AKT-eNOS-nitric oxide pathway as a potential mechanism underlying SPSS formation. Pharmacologic activation of AKT with SC79 reduced the incidence of SPSS and alleviated cirrhosis severity in vivo, suggesting that this pathway may represent a promising therapeutic target in cirrhosis with portal hypertension. |
| Citation |
Ke Q, Guo ZT, He J, Huang XH, Lei XJ, Zhuang QY, Zhou Y, Li L, Wang YC, Liu JF, Guo WH. AKT-eNOS-NO pathway mediates spontaneous portosystemic shunts and therapeutic efficacy of SC79 in cirrhosis. World J Gastroenterol 2026; In press |
