Publication Name	World Journal of Hepatology
Manuscript ID	120087
Country	Mexico

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Systemic inflammation in metabolic dysfunction-associated steatotic liver disease: Biological relevance and diagnostic limits
Manuscript Source	Invited Manuscript
All Author List	Mariana M Ramírez-Mejía and Nahum Méndez-Sánchez
Funding Agency and Grant Number
Corresponding Author	Nahum Méndez-Sánchez, Liver Research Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Colonia Toriello Guerra, Mexico City 14050, Mexico. nmendez@medicasur.org.mx
Key Words	Metabolic dysfunction-associated steatotic liver disease; Systemic inflammation; Liver fibrosis; C-reactive protein; Biological relevance; Diagnostic limit
Core Tip	Several markers have been developed to assess systemic inflammation in metabolic dysfunction-associated steatotic liver disease, including blood cell-derived indices and C-reactive protein. Yet, a statistical association with fibrosis does not make them clinically useful. Duarte et al confirm this using National Health and Nutrition Examination Survey data. Although indices such as the neutrophil-to-lymphocyte ratio and systemic inflammatory response index are associated with fibrosis, their discriminatory power is limited. C-reactive protein performs only slightly better. This suggests that inflammatory markers should be considered contextual risk modifiers. Not standalone diagnostic tools for fibrosis detection. Future strategies should prioritize biomarkers that more directly capture fibrogenic activity.
Citation	Ramírez-Mejía MM, Méndez-Sánchez N. Systemic Inflammation in Systemic inflammation in metabolic dysfunction-associated steatotic liver disease: Biological relevance and diagnostic limits: Biological Relevance and Diagnostic Limits. World J Hepatol 2026; In press

Received	2026-02-14 01:58
Peer-Review Started	2026-02-14 02:01
First Decision by Editorial Office Director	2026-02-26 07:27
Return for Revision	2026-02-26 07:27
Revised	2026-03-06 18:09
Publication Fee Transferred
Second Decision by Editor	2026-05-18 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 08:47
Articles in Press	2026-05-18 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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