Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	120090
Country	Egypt

Category	Pediatrics
Manuscript Type	Prospective Study
Article Title	Modality matters: Effect of dialysis modality on soluble intercellular adhesion molecule-1 in children on regular hemodialysis
Manuscript Source	Invited Manuscript
All Author List	Mohammed F Kasem, Ragia M Said, Doaa R Dahshan, Samar H Elhadedy, Noha R Mohammed and Noha U Hashem
Funding Agency and Grant Number
Corresponding Author	Ragia M Said, Professor, Division of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ain Shams University, 38 Abbassia Square, Next to Al-Nour Mosque, Cairo 1181, Egypt. ragia_marei@med.asu.edu.eg
Key Words	Soluble intercellular adhesion molecule-1; Hemodialysis; Online hemodiafiltration; Chronic kidney disease; Low-flux hemodialysis; High-flux hemodialysis
Core Tip	Children on chronic hemodialysis (HD) are exposed to persistent inflammation, which contributes to endothelial activation and cardiovascular risk. The type of dialysis modality may influence this inflammatory burden. This study evaluates the effect of low-flux HD, high-flux HD, and online hemodiafiltration (OL-HDF) on circulating intercellular adhesion molecule-1 (ICAM-1), a marker of endothelial activation, in pediatric patients. Low-flux HD increased post-session soluble ICAM-1 levels, suggesting dialysis-related endothelial injury, whereas high-flux HD and OL-HDF significantly reduced its levels, with OL-HDF normalizing ICAM-1 to values comparable to healthy controls. These findings suggest that selecting more biocompatible and high-efficiency dialysis modalities may help mitigate dialysis-related inflammation and potentially reduce long-term endothelial activation in pediatric HD patients.
Citation	Kasem MF, Said RM, Dahshan DR, Elhadedy SH, Mohammed NR, Hashem NU. Modality matters: Effect of dialysis modality on soluble intercellular adhesion molecule-1 in children on regular hemodialysis. World J Clin Pediatr 2026; In press

Received	2026-02-14 00:42
Peer-Review Started	2026-02-14 01:45
First Decision by Editorial Office Director	2026-03-03 09:30
Return for Revision	2026-03-03 09:30
Revised	2026-03-16 16:07
Publication Fee Transferred
Second Decision by Editor	2026-05-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-15 07:06
Articles in Press	2026-05-15 07:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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