| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Metabolic memory in the gut: The microbiota-epigenetic crosstalk orchestrating obesity onset and novel therapeutic landscapes
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yun Liu, Yu-Jue Wang, Shuai-Yan Wang, Cong-Yi Xie, Mo Zhou, En-He Zhao, Xin-Yu Shen, Jing-Yan Pan, Bin Xu and Tian-Cheng Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82305376 |
| Youth Talent Support Project of the China Acupuncture and Moxibustion Association |
2024-2026ZGZJXH-QNRC005 |
| 2024 Jiangsu Province Youth Science and Technology Talent Support Project |
JSTJ-2024-380 |
| Talent Cultivation Program for Young Researchers, Key Laboratory of the Ministry of Education Project |
zyqt202501, zyqt202503 |
|
| Corresponding Author |
Tian-Cheng Xu, Academic Fellow, CEO, Chairman, Director, PhD, Principal Investigator, Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Metabolic memory; Gut microbiota; Epigenetic; Obesity; Microbiota-epigenetic crosstalk; Intergenerational transmission; Butyrate |
| Core Tip |
The gut serves as a critical repository for metabolic memory, where transient exposure to obesogenic diets triggers persistent microbiota-epigenetic crosstalk. Specific microbial shifts, such as the enrichment of Odoribacter, lead to sustained epigenetic modifications like histone hyperacetylation via butyrate, driving chronic inflammation and obesity even after dietary normalization. This memory can be vertically transmitted to offspring, increasing intergenerational obesity susceptibility. Breaking this cycle requires time-sensitive interventions, including microbiota modulation and epigenetic therapies to restore metabolic homeostasis. |
| Citation |
Liu Y, Wang YJ, Wang SY, Xie CY, Zhou M, Zhao EH, Shen XY, Pan JY, Xu B, Xu TC. Metabolic memory in the gut: The microbiota-epigenetic crosstalk orchestrating obesity onset and novel therapeutic landscapes. World J Gastroenterol 2026; In press |
