Publication Name	World Journal of Cardiology
Manuscript ID	120186
Country	Russia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Systematic Reviews
Article Title	Anticoagulants vs thrombolytic therapy for the management of right heart thrombus in pulmonary embolism: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Kristina G Pereverzeva, Sergey S Yakushin and Natalia N Peregudova
Funding Agency and Grant Number
Corresponding Author	Sergey S Yakushin, Department of Hospital Therapy with a Course in Medical and Social Expertise, Federal State Budgetary Educational Institution of Higher Education I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation, 96 Stroykova Street, Ryazan 390026, Russia. s.yakushin@rzgmu.ru
Key Words	Right heart thrombi; Pulmonary embolism; Thrombolytic therapy; Anticoagulants; Mortality; Heparin; Hemodynamic instability
Core Tip	Management of patients with right heart thrombi in pulmonary embolism (PE) remains challenging. This meta-analysis of 205 patients did not reveal a significant advantage of routine thrombolytic therapy over isolated anticoagulation in reducing mortality. Our data do not support universal use of either strategy. Treatment decisions should be individualized, and clinicians should follow current guidelines, which recommend thrombolysis for hemodynamically unstable patients with massive PE.
Citation	Pereverzeva KG, Yakushin SS, Peregudova NN. Anticoagulants vs thrombolytic therapy for the management of right heart thrombus in pulmonary embolism: A systematic review. World J Cardiol 2026; In press

Received	2026-02-28 02:06
Peer-Review Started	2026-02-28 02:06
First Decision by Editorial Office Director	2026-04-04 02:27
Return for Revision	2026-04-04 02:27
Revised	2026-04-21 17:59
Publication Fee Transferred
Second Decision by Editor	2026-05-06 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 07:44
Articles in Press	2026-05-06 07:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com