Publication Name	World Journal of Stem Cells
Manuscript ID	120270
Country	China

Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Fu-Xing Dong, Lu-Li Zheng, Kun Nie and Jian-Xin Wan
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Fujian Province 2021J01355
Corresponding Author	Jian-Xin Wan, Chief Physician, Professor, Department of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. wanjx@fjmu.edu.cn
Key Words	Human umbilical cord mesenchymal stem cells; Peritoneal fibrosis; Cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway; Epithelial-mesenchymal transition; Inflammation
Core Tip	The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is activated in peritoneal fibrosis (PF). This study shows that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate high glucose-induced epithelial-mesenchymal transition and murine PF. Mechanistically, hUC-MSCs exert protective effects by inhibiting the cGAS-STING axis. These findings identify hUC-MSCs as a promising therapeutic strategy to retard PF progression by targeting the cGAS-STING pathway in patients undergoing long-term peritoneal dialysis.
Citation	Dong FX, Zheng LL, Nie K, Wan JX. Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis. World J Stem Cells 2026; In press

Received	2026-02-24 03:13
Peer-Review Started	2026-02-24 03:13
First Decision by Editorial Office Director	2026-03-09 08:44
Return for Revision	2026-03-09 08:44
Revised	2026-04-02 06:52
Publication Fee Transferred	2026-04-07 06:39
Second Decision by Editor	2026-05-18 04:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-18 10:08
Articles in Press	2026-05-18 10:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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