Publication Name	World Journal of Gastroenterology
Manuscript ID	120350
Country	United States

Category	Immunology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Autoantibody profiling in gastric cancer immunotherapy - dynamic monitoring, toxicity-benefit trade-off, and immune endotypes
Manuscript Source	Invited Manuscript
All Author List	Wan-Ting Huang, Bin-Bin Zhang and Jia-Nan Zhao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Funds of China No. 82204827
Corresponding Author	Jia-Nan Zhao, Academic Fellow, Department of Cardiovascular Sciences, Temple University, North Carlisle Street, 3440 Carlisle st, Philadelphia, PA 19140, United States. tuv36393@temple.edu
Key Words	Gastric cancer; Antinuclear antibody; Extractable nuclear antigen; Immunotherapy; Immune endotype
Core Tip	Baseline antinuclear antibody/extractable nuclear antigen status may serve as a potential predictor of immunotherapy outcomes in gastric cancer. However, static indicators fail to capture dynamic autoantibody changes or the underlying differences in immune endotypes. We propose to build a composite host-tumor model that integrates longitudinal antibody profiles, detailed staining patterns, and safety data, and apply calibration curves and decision curve analysis to evaluate its net clinical benefit, thereby promoting the establishment of more refined risk stratification strategies and facilitating the practice of personalized immuno-oncology.
Citation	Huang WT, Zhang BB, Zhao JN. Letter to the Editor: Autoantibody profiling in gastric cancer immunotherapy - dynamic monitoring, toxicity-benefit trade-off, and immune endotypes. World J Gastroenterol 2026; In press

Received	2026-02-24 05:46
Peer-Review Started	2026-02-24 05:48
First Decision by Editorial Office Director	2026-03-27 12:54
Return for Revision	2026-03-27 12:54
Revised	2026-04-04 14:43
Publication Fee Transferred
Second Decision by Editor	2026-05-12 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-12 08:30
Articles in Press	2026-05-12 08:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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