| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Regulation of ferroptosis and mitochondrial homeostasis disruption in diabetic cardiomyopathy: Therapeutic potential of traditional Chinese medicine
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Ting Tang, Qian Wu, Yu-Peng Chen, Ling Xia, Martina Hong Yang, Mao-Ying Wei, Qing Pang, Ya-Nan Yang, Jing-Bo Liu, Jun-Li Liu, Qing Ni and Yan-Bing Gong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Scholarship Council |
202406550024 |
| Postdoctoral Fellowship Program of China Postdoctoral Science Foundation |
GZC20230324 and 2024M750263 |
| National Key R&D Program of China |
2024ZD0523503 |
| Shuangshou Health Initiative |
01060030 |
| Leading Talent Training Program Project of Dongzhimen Hospital of Beijing University of Chinese Medicine |
DZMG-LJRC0004 |
| Fundamental Research Funds for the Central Universities |
2023-JYB-JBZD-010 |
|
| Corresponding Author |
Yan-Bing Gong, Professor, /, Beijing University of Chinese Medicine, No. 11 North Third Ring East Road, Chaoyang District, Beijing 100029, China. 20230941125@bucm.edu.cn |
| Key Words |
Diabetic cardiomyopathy; Ferroptosis; Mitochondrial dysfunction; Iron metabolism; Multi-target therapy |
| Core Tip |
Tang YT, Wu Q, Chen YP, Xia L, Yang MH, Wei MY, Pang Q, Yang YN, LIU J, Liu JL, Ni Q, Gong YB. Regulation of ferroptosis and mitochondrial homeostasis disruption in diabetic cardiomyopathy: Therapeutic potential of traditional Chinese medicine. World J Diabetes 2026; In press Core Tip: Diabetic cardiomyopathy (DCM) is often clinically silent until heart failure develops, and disease-specific therapies remain unavailable. This review examines the interaction between ferroptosis and mitochondrial dysfunction in DCM, linking iron dyshomeostasis, reactive oxygen species overload, impaired antioxidant defenses, and disrupted mitochondrial quality control. We compare evidence and limitations of glucose-lowering drugs, mechanism-targeted approaches (iron chelators and mitochondrial protectants), and multi-target traditional Chinese medicine and bioactive compounds. We propose that combination strategies co-targeting ferroptosis and mitochondrial pathways, particularly multi-target traditional Chinese medicine and its bioactive compounds, may offer a promising approach for more effective and individualized DCM treatment. |
| Citation |
Tang YT, Wu Q, Chen YP, Xia L, Yang MH, Wei MY, Pang Q, Yang YN, Liu JB, Liu JL, Ni Q, Gong YB. Regulation of ferroptosis and mitochondrial homeostasis disruption in diabetic cardiomyopathy: Therapeutic potential of traditional Chinese medicine. World J Diabetes 2026; In press |
