Publication Name	World Journal of Gastroenterology
Manuscript ID	120450
DOI	10.3748/wjg.120450
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Yun Zhuo, Xiao-Ya Guo, Xiao-Ming Liu, Ming-Mei Shang, Shan Xue, Lei Peng and Zhi-Guo Guo
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82400621 Anhui Provincial Health Science and Technology Project AHWJ2024Aa20059 Anhui Province Traditional Chinese Medicine Inheritance Innovation Project 2024CCCX271 Anhui Province Education Department Project 2023jyxm1156
Corresponding Author	Zhi-Guo Guo, MD, Professor, Department of Gastroenterology, Suzhou Hospital of Anhui Medical University, No. 616 Bianyangsan Road, Suzhou 234000, Anhui Province, China. guozhiguo@ahmu.edu.cn
Key Words	Ulcerative colitis; Extracts of Gleditsia sinensis Lam. thorn; Peroxisome proliferator-activated receptor gamma/glutathione peroxidase 4; Bile acids; Ferroptosis
Core Tip	Extracts of Gleditsia sinensis Lam. thorn (EGST) ameliorates dextran sulfate sodium-induced ulcerative colitis. EGST inhibited the ferroptosis of erastin-induced Caco-2 cells. EGST regulates nitric oxide and reactive oxygen species inhibit lipid peroxidation. EGST activated the peroxisome proliferator-activated receptor gamma/glutathione peroxidase 4 signaling pathway and inhibit ferroptosis. We report for the first time that EGST alleviates colitis in mice by regulating taurohyodeoxycholic acid.
Citation	Zhuo ZY, Guo XY, Liu XM, Shang MM, Xue S, Peng L, Guo ZG. Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.120450
PDF	120450-in-press.pdf

Received	2026-02-28 01:24
Peer-Review Started	2026-02-28 01:24
First Decision by Editorial Office Director	2026-03-20 11:30
Return for Revision	2026-03-20 11:30
Revised	2026-04-23 16:45
Publication Fee Transferred	2026-04-28 09:32
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 06:41
Articles in Press	2026-06-22 06:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com