Publication Name	World Journal of Psychiatry
Manuscript ID	120501
Country	China

Category	Psychiatry
Manuscript Type	Review
Article Title	Nuclear factor-κB as a key inflammatory mediator in psychiatric diseases: A narrative review
Manuscript Source	Invited Manuscript
All Author List	Fei Fan, Bo Wang, Qiong Wang, Zi-Lin Chen, Wei-Feng Li and Fei Han
Funding Agency and Grant Number	Funding Agency Grant Number The Fundamental Research Funds for the Central Public Welfare Research Institutes ZZ17-XRZ-043
Corresponding Author	Fei Han, Department of Paediatrics, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange Road, Xicheng District, Beijing 100053, China. hf4383@126.com
Key Words	Nuclear factor-κB; Psychiatric diseases; Neuroinflammation; Microglia; Astrocytes; Synaptic plasticity; Immune dysregulation
Core Tip	Nuclear factor-κB (NF-κB) is a central transcription factor linking peripheral immune dysregulation to neuroinflammation in psychiatric disorders. It exerts cell-type-specific effects on microglia, astrocytes, and neurons, interacting with nuclear factor erythroid 2-related factor 2, hypoxia-inducible factor 1-alpha, and NOD-like receptor family pyrin domain containing 3 pathways. Targeting NF-κB and its regulators offers promising therapeutic potential for personalized psychiatry.
Citation	Fan F, Wang B, Wang Q, Chen ZL, Li WF, Han F. Nuclear factor-κB as a key inflammatory mediator in psychiatric diseases: A narrative review. World J Psychiatry 2026; In press

Received	2026-02-28 02:17
Peer-Review Started	2026-02-28 02:18
First Decision by Editorial Office Director	2026-03-17 06:55
Return for Revision	2026-03-17 06:55
Revised	2026-03-21 11:55
Publication Fee Transferred
Second Decision by Editor	2026-05-06 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 10:18
Articles in Press	2026-05-06 10:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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