Publication Name	World Journal of Cardiology
Manuscript ID	120519
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression
Manuscript Source	Unsolicited Manuscript
All Author List	Fu-Ying Chu, Meng-Han Yao, Le-Ming Gu, Hua Cai, Ya-Nan Li, Xiang Chen and Xin-Xin Xu
Funding Agency and Grant Number	Funding Agency Grant Number Wu Jieping Medical Foundation 320.6750.2024-03-70
Corresponding Author	Xin-Xin Xu, Department of Laboratory Medicine, Affiliated Hospital of Nantong University, No. 20 Xisi Road, Chongchuan District, Nantong 226000, Jiangsu Province, China. xxxin891119@163.com
Key Words	Sphingosine-1-phosphate receptor 1; Coronary atherosclerotic heart disease; Oxidized low-density lipoprotein; Interleukin-1β; Tumor necrosis factor-α
Core Tip	In this study, sphingosine-1-phosphate receptor 1 (S1PR1) is upregulated in coronary atherosclerotic heart disease and positively correlates with interleukin-1β and tumor necrosis factor-α. It serves as a promising diagnostic biomarker, and combined detection with inflammatory cytokines enhances diagnostic performance. S1PR1 knockdown alleviates oxidized low-density lipoprotein-induced endothelial cell injury via modulating inflammatory responses, highlighting S1PR1 as a potential target for coronary atherosclerotic heart disease diagnosis and intervention.
Citation	Chu FY, Yao MH, Gu LM, Cai H, Li YN, Chen X, Xu XX. S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression. World J Cardiol 2026; In press

Received	2026-03-09 03:34
Peer-Review Started	2026-03-09 03:35
First Decision by Editorial Office Director	2026-03-20 10:46
Return for Revision	2026-03-20 10:46
Revised	2026-04-01 11:29
Publication Fee Transferred
Second Decision by Editor	2026-04-24 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-24 06:58
Articles in Press	2026-04-24 06:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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