Publication Name	World Journal of Hepatology
Manuscript ID	120591
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	LGALS3 signaling and macrophage ferroptosis in steatohepatitis
Manuscript Source	Invited Manuscript
All Author List	Wei Liu and Zhuo-Jin Shi
Funding Agency and Grant Number
Corresponding Author	Zhuo-Jin Shi, DDS, School/Hospital of Stomatology, Zhejiang Chinese Medical University, No.548 Binwen Road, Hangzhou 310053, Zhejiang Province, China. szj@zcmu.edu.cn
Key Words	Metabolic dysfunction-associated steatohepatitis; LGALS3; Ferroptosis; GPX4; Macrophage; Traditional Chinese medicine; Botanical drug development; Fibrosis
Core Tip	Macrophage-linked ferroptosis has emerged as a plausible injury-amplifying layer in steatohepatitis. A recent study of Qiweizhigan granule proposes an LGALS3-TRAF6-GPX4 framework connecting inflammatory activation to ferroptotic vulnerability. Its main value lies in generating a testable translational model rather than a settled mechanism. Future progress will depend on cell-specific causality, human-relevant validation, mechanism-linked potency assays, and clinically deployable biomarker strategies.
Citation	Liu W, Shi ZJ. LGALS3 signaling and macrophage ferroptosis in steatohepatitis. World J Hepatol 2026; In press

Received	2026-03-03 03:32
Peer-Review Started	2026-03-03 03:33
First Decision by Editorial Office Director	2026-03-17 10:42
Return for Revision	2026-03-17 11:36
Revised	2026-04-04 04:37
Publication Fee Transferred
Second Decision by Editor	2026-05-15 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-15 06:03
Articles in Press	2026-05-15 06:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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