Publication Name	World Journal of Gastroenterology
Manuscript ID	120646
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Long-term lymphoma risk in thiopurine-treated inflammatory bowel disease: A 15-year propensity-matched cohort study
Manuscript Source	Invited Manuscript
All Author List	Manjeet K Goyal, Rishi Chowdhary, Megh Patel, Marc Landsman, Kirti Arora, Shivam Kalra, Rahul Chowdhary, Ashita R Vuthaluru, Sowmya Durga Subhasri Guna and Vishal Sharma
Funding Agency and Grant Number
Corresponding Author	Manjeet K Goyal, Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi 110029, India. manjeetgoyal@gmail.com
Key Words	Inflammatory bowel diseases; Thiopurine; Lymphoma; Immunosuppressive agents; Risk assessment; Advanced therapy; Drug-related side effects and adverse reactions
Core Tip	Thiopurines remain central to maintenance therapy in inflammatory bowel disease (IBD), yet concerns about lymphoma risk complicate long-term use. This large, propensity-matched cohort study clarifies the temporal dynamics of malignancy risk, using 5-aminosalicylates as a safe active comparator. We demonstrate that thiopurines are not associated with increased lymphoma risk during the first three years of therapy, with risk elevation emerging only after prolonged use. These findings support a time-dependent, immune suppression-linked oncogenic mechanism and provide a rational basis for limited-duration thiopurine therapy with individualized risk stratification to maximize safety in IBD care.
Citation	Goyal MK, Chowdhary R, Patel M, Landsman M, Arora K, Kalra S, Chowdhary R, Vuthaluru AR, Subhasri Guna SD, Sharma V. Long-term lymphoma risk in thiopurine-treated inflammatory bowel disease: A 15-year propensity-matched cohort study. World J Gastroenterol 2026; In press

Received	2026-03-06 02:18
Peer-Review Started	2026-03-06 02:18
First Decision by Editorial Office Director	2026-04-03 09:10
Return for Revision	2026-04-03 09:10
Revised	2026-04-07 01:39
Publication Fee Transferred
Second Decision by Editor	2026-05-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-15 07:41
Articles in Press	2026-05-15 07:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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