Publication Name	World Journal of Diabetes
Manuscript ID	120779
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Case Control Study
Article Title	Irisin levels in patients with prediabetes mellitus: A case-control study and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Wen Song, Wen-Wen Huang, Li-Na Chang, Xin Wang, Qian-Qian Sun, Xiao-Long Wang and Qing He
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Development Project of the Affiliated Hospital of Weifang Medical University Funds 2023FYM015 Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-3-002C
Corresponding Author	Qing He, Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin Medical University General Hospital, 300052, Tianjin, China, Tianjin 300052, China. heqing202301@tmu.edu.cn
Key Words	Irisin; Prediabetes mellitus; Enzyme-linked immunosorbent assay; Methodological variability; Standardization; Case-control study; Meta-analysis
Core Tip	This study suggests that methodological variability between commercial enzyme-linked immunosorbent assay kits may contribute to the conflicting literature on circulating irisin in prediabetes, supported by poor inter assay agreement in this cohort. After rigorously controlling for metabolic confounders, the observed association between prediabetes and irisin disappears, shifting the focus from irisin as a simple biomarker to the critical need for assay standardization and robust study design in future research.
Citation	Song LW, Huang WW, Chang LN, Wang X, Sun QQ, Wang XL, He Q. Irisin levels in patients with prediabetes mellitus: A case-control study and meta-analysis. World J Diabetes 2026; In press

Received	2026-03-09 01:20
Peer-Review Started	2026-03-12 23:47
First Decision by Editorial Office Director	2026-03-20 10:11
Return for Revision	2026-03-20 10:11
Revised	2026-04-02 14:39
Publication Fee Transferred	2026-04-07 11:09
Second Decision by Editor	2026-05-07 05:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-14 09:09
Articles in Press	2026-05-14 09:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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