Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	120832
Country	Russia

Category	Pediatrics
Manuscript Type	Retrospective Cohort Study
Article Title	Does Takayasu arteritis differ between children and adolescents? Insights from a Russian multicenter cohort
Manuscript Source	Invited Manuscript
All Author List	Vera A Podzolkova, Natalia A Geppe, Anastasia A Glazyrina, Sania I Valieva, Ilia S Avrusin, Seda Kh Kurbanova, Svetlana S Vakhlyarskaya, Yulia O Kostina, Valeria T Yudina, Ekaterina A Lagutina, Maria K Osminina, Elena S Zholobova, Nadezhda S Podchernyaeva, Eva P Turginekova, Lyubov S Sorokina, Siuzanna A Davtian and Mikhail M Kostik
Funding Agency and Grant Number
Corresponding Author	Mikhail M Kostik, MD, PhD, Professor, Department of Hospital Pediatry, Saint Petersburg State Pediatric Medical University, Lytovskaya 2, Saint Petersburg 194100, Sankt-Peterburg, Russia. kost-mikhail@yandex.ru
Key Words	Takayasu arteritis; Children; Adolescents; Vasculitis; Age; Surgery; Disease-modifying anti-rheumatic drugs; Biological drugs; Tocilizumab; Russia
Core Tip	In this first Russian multicenter cohort study, childhood-onset Takayasu arteritis (TA) presents with distinct age-specific clinical phenotypes. Younger children (< 10 years) exhibit lower inflammatory activity but paradoxically require more frequent surgical interventions, suggesting a “burnt-out” presentation at diagnosis due to diagnostic delays. Vascular damage progresses in one-third of patients despite normalized laboratory parameters, confirming the dissociation between systemic inflammation and vessel wall injury. Tocilizumab was the predominant biologic choice with favorable outcomes. These findings emphasize that conventional inflammatory markers are insufficient for monitoring disease activity and that age-specific management strategies are essential for improving long-term outcomes in pediatric TA.
Citation	Podzolkova VA, Geppe NA, Glazyrina AA, Valieva SI, Avrusin IS, Kurbanova SK, Vakhlyarskaya SS, Kostina YO, Yudina VT, Lagutina EA, Osminina MK, Zholobova ES, Podchernyaeva NS, Turginekova EP, Sorokina LS, Davtian SA, Kostik MM. Does Takayasu arteritis differ between children and adolescents? Insights from a Russian multicenter cohort. World J Clin Pediatr 2026; In press

Received	2026-03-10 01:19
Peer-Review Started	2026-03-10 01:19
First Decision by Editorial Office Director	2026-03-20 10:51
Return for Revision	2026-03-20 10:51
Revised	2026-03-31 14:26
Publication Fee Transferred
Second Decision by Editor	2026-04-16 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-16 07:51
Articles in Press	2026-04-16 07:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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