Publication Name	World Journal of Methodology
Manuscript ID	120850
Country	Greece

Category	Surgery
Manuscript Type	Review
Article Title	Beyond hormones, cholesterol metabolism as a modulator of estrogen receptor-positive luminal breast cancer
Manuscript Source	Invited Manuscript
All Author List	Alexandra G Marneri, Efstathios T Pavlidis, Kalliopi E Stavrati, Christina Mouratidou, Athanasios Kofinas and Theodoros E Pavlidis
Funding Agency and Grant Number
Corresponding Author	Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Key Words	Breast cancer; Luminal breast cancer; Cholesterol metabolism in cancer; Statins in cancer; Resistance to endocrine therapy; Targeted agents; Estrogen receptors
Core Tip	Estrogen receptor-positive luminal breast cancer is the most common molecular subtype and continues to be a primary clinical concern due to its extended natural course and ongoing risk of late recurrence. Current treatment strategies are primarily based on endocrine therapy, which is often combined with targeted agents. Nevertheless, resistance to endocrine therapy can develop. Emerging evidence highlights the significant role of cholesterol metabolism in estrogen receptor-positive luminal breast cancer, which should be characterized as cholesterol-sensitive rather than statin-dependent. The development of a metabolic framework specific to this subtype may facilitate the interpretation of existing data and inform future research initiatives.
Citation	Marneri AG, Pavlidis ET, Stavrati KE, Mouratidou C, Kofinas A, Pavlidis TE. Beyond hormones, cholesterol metabolism as a modulator of estrogen receptor-positive luminal breast cancer. World J Methodol 2026; In press

Received	2026-03-10 01:39
Peer-Review Started	2026-03-10 01:40
First Decision by Editorial Office Director	2026-04-13 09:23
Return for Revision	2026-04-13 09:23
Revised	2026-04-14 14:37
Publication Fee Transferred
Second Decision by Editor	2026-04-24 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-24 07:38
Articles in Press	2026-04-24 07:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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