Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	120889
Country	China

Category	Oncology
Manuscript Type	Case Report
Article Title	Prophylactic cholecystectomy for asymptomatic gallstone disease: Two case reports and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Jian Zhang, Bin Xi, Jin Li, Liang Wen, Yu Deng, Chao-Wei Wang and Yun Zhang
Funding Agency and Grant Number	Funding Agency Grant Number the Natural Science Foundation of Zhejiang Province LMRZ26H180001, LY21H100003, LD19H150001
Corresponding Author	Yun Zhang, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310000, Zhejiang Province, China. bigzyun1977@zju.edu.cn
Key Words	Case report; Asymptomatic gallstone disease; Silent gallbladder stones; Prophylactic cholecystectomy; Xanthogranulomatous cholecystitis; Gallbladder cancer
Core Tip	Whether the gallbladder should be removed prophylactically for asymptomatic gallstone disease (AGD) is still debated. We herein describe two cases with a long history of AGD. In the first case, magnetic resonance imaging suggested gallbladder cancer with liver involvement, but postoperative pathology demonstrated xanthogranulomatous cholecystitis. In the second case, imaging suggested metastatic gallbladder cancer, and biopsy confirmed the diagnosis. Although prophylactic cholecystectomy is not indicated for all AGDs to avoid future risk, annual follow-up is urgently needed. If signs of abnormality or risk factors are present, timely surgery is suggested.
Citation	Zhang J, Xi B, Li J, Wen L, Deng Y, Wang CW, Zhang Y. Prophylactic cholecystectomy for asymptomatic gallstone disease: Two cases report and review of literature. World J Gastrointest Oncol 2026; In press

Received	2026-03-11 02:53
Peer-Review Started	2026-03-11 02:54
First Decision by Editorial Office Director	2026-03-26 09:40
Return for Revision	2026-03-26 09:40
Revised	2026-04-08 07:54
Publication Fee Transferred	2026-04-13 12:38
Second Decision by Editor	2026-05-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-15 08:18
Articles in Press	2026-05-15 08:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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