Publication Name	World Journal of Gastroenterology
Manuscript ID	121126
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Peptide receptor radionuclide therapy for recurrent neuroendocrine tumors after liver transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Qi-Ming Zheng, Chi-Yi Chen, Li Zhang, Ji-San Sun, Hong-Hai Wang, Yan Xie, Qing-Jun Guo and Wen-Tao Jiang
Funding Agency and Grant Number	Funding Agency Grant Number Key Project of Tianjin Science and Technology Bureau Applied Basic Research No. 23JCZDJC01200 Independent Research Fund of the Institute of Transplant Medicine at Nankai University No. NKTM2023004 Tianjin Key Medical Discipline Construction Project No. TJYXZDXK-3-006A-1
Corresponding Author	Wen-Tao Jiang, MD, PhD, Principal Investigator, Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, No. 2 Baoshan West Road, Xiqing District, Tianjin 300192, China. jiangwentao@nankai.edu.cn
Key Words	Liver transplantation; Neuroendocrine tumors; Liver metastasis; Peptide receptor radionuclide therapy; Recurrence; Progression-free survival
Core Tip	This retrospective comparative cohort study evaluates lutetium Lu 177 dotatate (177Lu-DOTATATE) peptide receptor radionuclide therapy (PRRT) combined with everolimus in somatostatin receptor-positive G2 neuroendocrine tumor liver metastases after liver transplantation. In 7 PRRT-treated patients vs 8 controls, PRRT achieved a disease control rate of 85.7% and significantly improved progression-free survival (log-rank P = 0.028), with manageable hematologic toxicity (grade III in 28.6%) and no graft rejection. These hypothesis-generating findings suggest PRRT as a promising option for this rare cohort.
Citation	Zheng QM, Chen CY, Zhang L, Sun JS, Wang HH, Xie Y, Guo QJ, Jiang WT. Peptide receptor radionuclide therapy for recurrent neuroendocrine tumors after liver transplantation. World J Gastroenterol 2026; In press

Received	2026-03-17 02:30
Peer-Review Started	2026-03-17 02:30
First Decision by Editorial Office Director	2026-04-04 03:32
Return for Revision	2026-04-04 03:32
Revised	2026-04-15 03:21
Publication Fee Transferred	2026-04-16 06:50
Second Decision by Editor	2026-04-24 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-24 10:48
Articles in Press	2026-04-24 10:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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