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Articles in Press
10/12/2026 10:11:58 AM | Browse: 13 | Download: 3
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
HMGA2 promotes epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via transforming growth factor-β/small mothers against decapentaplegic 2
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Ning Zhang, Jin-Yong Hao, Xia Lei, Peng-Fei Wang, Shao-Ce Xu and Xiao-Jun Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital |
No. CY2023-MS-A09 |
| College Teachers Innovation Fund of Gansu Province, China |
No. 2025B-019 |
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| Corresponding Author |
Xiao-Jun Huang, Department of Gastroenterology, Lanzhou University Second Hospital, No. 82 Cuiying Gate, Chengguan District, Lanzhou 730000, Gansu Province, China. huang_xiaojunn@163.com |
| Key Words |
Intrahepatic cholangiocarcinoma; HMGA2; Transforming growth factor-β; Small mothers against decapentaplegic 2 signaling; Epithelial-mesenchymal transition |
| Core Tip |
This study demonstrates that HMGA2 is overexpressed in intrahepatic cholangiocarcinoma (ICC) and independently predicts poor prognosis. Functional experiments showed that HMGA2 promotes ICC cell proliferation, migration, invasion, and tumor growth. Mechanistically, HMGA2 activates the transforming growth factor-β/small mothers against decapentaplegic 2 signaling pathway and induces epithelial-mesenchymal transition, thereby driving ICC progression. These findings highlight HMGA2 as a potential prognostic biomarker and therapeutic target for ICC. |
| Citation |
Zhang YN, Hao JY, Lei X, Wang PF, Xu SC, Huang XJ. HMGA2 promotes epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via transforming growth factor-β/small mothers against decapentaplegic 2. World J Gastrointest Oncol 2026; In press
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| PDF |
121485-in-press.pdf
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Received |
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2026-04-07 05:59 |
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Peer-Review Started |
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2026-04-08 00:08 |
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First Decision by Editorial Office Director |
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2026-06-04 03:31 |
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Return for Revision |
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2026-06-04 03:31 |
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Revised |
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2026-07-01 06:54 |
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Publication Fee Transferred |
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2026-08-19 13:37 |
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Second Decision by Editor |
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2026-10-12 03:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-12 10:11 |
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Articles in Press |
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2026-10-12 10:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
