Publication Name	World Journal of Clinical Oncology
Manuscript ID	121645
DOI	10.5306/wjco.121645
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Copper homeostasis imbalance and cuproptosis: Emerging targets and strategies for gastrointestinal tumor therapy
Manuscript Source	Invited Manuscript
All Author List	Zi-Jin Sun, Kai Wang, Jin-Qiao Li, Lin-Jing Song, Kang-Ni Liang, Ting-Lan Cao and Hui-Zhong Jiang
Funding Agency and Grant Number
Corresponding Author	Hui-Zhong Jiang, PhD, Professor, Researcher, Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Beijing 100700, China. jianghz93@126.com
Key Words	Gastrointestinal neoplasms; Cuproptosis; Metabolic reprogramming; Ferredoxin 1; Nanomedicine; Traditional Chinese medicine; Gut microbiota
Core Tip	Gastrointestinal malignancies exhibit profound metabolic reprogramming and “cuproplasia”, heavily relying on copper homeostasis for progression and drug resistance. Targeting cuproptosis - a ferredoxin 1-mediated cell death causing toxic aggregation of lipoylated proteins like dihydrolipoamide S-acetyltransferase - offers a transformative strategy to bypass conventional therapeutic resistance. This review highlights multifaceted interventions, including repurposing synthetic copper ionophores, leveraging traditional Chinese medicine phytochemicals, and modulating the unique “dietary copper-gut microbiota” axis. Furthermore, deploying stimuli-responsive nanomedicines helps overcome dense stromal barriers and induces immunogenic cell death, synergizing with immunotherapy to advance the precision management of refractory gastrointestinal tumors.
Citation	Sun ZJ, Wang K, Li JQ, Song LJ, Liang KN, Cao TL, Jiang HZ. Copper homeostasis imbalance and cuproptosis: Emerging targets and strategies for gastrointestinal tumor therapy. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.121645
PDF	121645-in-press.pdf

Received	2026-03-30 08:11
Peer-Review Started	2026-03-30 08:16
First Decision by Editorial Office Director	2026-04-23 09:54
Return for Revision	2026-04-23 10:51
Revised	2026-05-12 08:14
Publication Fee Transferred
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 03:24
Articles in Press	2026-06-22 03:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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