Publication Name	World Journal of Nephrology
Manuscript ID	121696
DOI	10.5527/wjn.121696
Country	India

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Depression in chronic kidney disease and dialysis: A psychonephrology narrative review
Manuscript Source	Invited Manuscript
All Author List	Monika Yadav, Adarsh Kumar, Abhinav Pandey, Swarndeep Singh, Rajesh Kumar, Himanshu Verma, Sanjiv Mahajan, Sourabh Sharma, Pallavi Prasad and Anupam Agarwal
Funding Agency and Grant Number
Corresponding Author	Adarsh Kumar, Associate Professor, DM, MD, Department of Nephrology, Vardhman Mahavir Medical College (VMMC) and Safdarjung Hospital, Ansari Nagar West, Aurobindo Marg, Ring Road, New Delhi 110029, DL, India. adarshnephro081@gmail.com
Key Words	Chronic kidney disease; Depression; Dialysis; Psychonephrology; Uremic toxins
Core Tip	Depression is one of the most common yet under-recognized comorbidities in chronic kidney disease (CKD), especially among patients receiving maintenance dialysis. Overlapping somatic symptoms of uremia often complicate its diagnosis, leading to under detection and undertreatment. Beyond its profound impact on quality of life, depression is associated with poor treatment adherence, increased hospitalization, malnutrition, reduced dialysis adequacy, and higher mortality. Emerging evidence suggests that inflammation, neuroendocrine dysregulation, uremic toxin accumulation, and psychosocial stressors collectively contribute to its pathogenesis. This review highlights the epidemiology, mechanisms, diagnostic challenges, and clinical consequences of depression across the CKD spectrum, while emphasizing the evolving role of psychonephrology in integrating psychological and renal care. Early recognition and multidisciplinary management are essential to improving holistic outcomes in CKD patients.
Citation	Yadav M, Kumar A, Pandey A, Singh S, Kumar R, Verma H, Mahajan S, Sharma S, Prasad P, Agarwal A. Depression in chronic kidney disease and dialysis: A psychonephrology narrative review. World J Nephrol 2026; In press DOI: https://doi.org/10.5527/wjn.121696
PDF	121696-in-press.pdf

Received	2026-03-31 05:56
Peer-Review Started	2026-03-31 05:59
First Decision by Editorial Office Director	2026-04-17 08:15
Return for Revision	2026-04-17 08:15
Revised	2026-05-22 06:25
Publication Fee Transferred
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 03:44
Articles in Press	2026-06-22 03:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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