Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	121737
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Endoscopic biliary drainage techniques for bilirubin normalization in distal malignant biliary obstruction: A comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Alberto Martino, Antonino Granata, Francesco Paolo Zito, Massimiliano Lombardi, Roberto Fiorentino, Claudio Carrubba, Luigi Orsini, Raffaella Niola, Ferdinando Riccardi, Giuseppe Galloro, Carlo Molino and Giovanni Lombardi
Funding Agency and Grant Number
Corresponding Author	Alberto Martino, Department of Gastroenterology and Digestive Endoscopy, AORN “Antonio Cardarelli”, Via Antonio Cardarelli 9, Napoli 80131, Italy. alberto.martino@aocardarelli.it
Key Words	Endoscopic retrograde cholangiopancreatography; Endoscopic ultrasound-guided biliary drainage; Endoscopic ultrasound-guided choledochoduodenostomy; Endoscopic ultrasound-guided gallbladder drainage; Biliary drainage; Distal malignant biliary obstruction; Malignant biliary obstruction; Bilirubin normalization
Core Tip	The therapeutic armamentarium for distal malignant biliary obstruction (DMBO) currently includes endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage, and various endoscopic ultrasound-guided biliary drainage techniques. Although ERCP remains the gold standard for DMBO, some endoscopic ultrasound-guided biliary drainage techniques are now considered the preferred second-line strategies and have also been proposed as promising first-line alternatives to ERCP. However, despite its key role in DMBO, the bilirubin normalization rate is underreported and evidence concerning the effectiveness of biliary drainage modalities for bilirubin normalization in DMBO is lacking, particularly for emerging strategies. Our study aimed to review the current evidence on the efficacy of available endoscopic biliary drainage modalities for bilirubin normalization in patients with DMBO.
Citation	Martino A, Granata A, Zito FP, Lombardi M, Fiorentino R, Carrubba C, Orsini L, Niola R, Riccardi F, Galloro G, Molino C, Lombardi G. Endoscopic biliary drainage techniques for bilirubin normalization in distal malignant biliary obstruction: A comprehensive review. World J Gastrointest Endosc 2026; In press

Received	2026-03-31 03:43
Peer-Review Started	2026-03-31 03:46
First Decision by Editorial Office Director	2026-04-16 07:29
Return for Revision	2026-04-18 09:12
Revised	2026-04-30 13:35
Publication Fee Transferred
Second Decision by Editor	2026-05-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-15 08:56
Articles in Press	2026-05-15 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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