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Publication Name World Journal of Gastroenterology
Manuscript ID 121899
Country China
Category Medicine, General & Internal
Manuscript Type Review
Article Title Targeting inflammasome in digestive diseases: A dual approach of Western and Chinese medicine
Manuscript Source Unsolicited Manuscript
All Author List Qing Qi, Cheng-Hui Zhu, Jia-Ling Li and Jing Yu
Funding Agency and Grant Number
Funding Agency Grant Number
Liaoning Province Science and Technology Plan Joint Plan (Natural Science Foundation-General Program) No. 2025-MSLH-495
Corresponding Author Jing Yu, Chief Physician, Professor, Department of Rheumatology, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Shenyang 110032, Liaoning Province, China. yujingliaoning@163.com
Key Words NOD-like receptor family pyrin domain-containing 3 inflammasome; Digestive system diseases; Inflammation; Traditional Chinese medicine; Therapeutic target; Pyroptosis; Gut-liver axis
Core Tip The activation of NOD-like receptor family pyrin domain-containing 3 inflammasome is connected with some digestive system diseases through inflammation and pyroptosis. At present, Western medicine focuses on this problem, but no inhibitor has been used in digestive diseases and some serious side effects (such as hepatotoxicity) also occur, together with unsuccessful clinical trials. On the contrary, traditional Chinese medicine regulates it from various aspects. A combined therapy involving both traditional Chinese medicine and Western medicine may exhibit an additive effect and provides a promising precise therapeutic approach for digestive disorders.
Citation Qi Q, Zhu CH, Li JL, Yu J. Targeting inflammasome in digestive diseases: A dual approach of Western and Chinese medicine. World J Gastroenterol 2026; In press
Received
2026-04-08 10:03
Peer-Review Started
2026-04-08 10:04
First Decision by Editorial Office Director
2026-04-29 08:54
Return for Revision
2026-04-29 08:54
Revised
2026-05-25 09:34
Publication Fee Transferred
2026-06-13 04:45
Second Decision by Editor
2026-09-17 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-09-17 09:27
Articles in Press
2026-09-17 09:27
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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