Publication Name	World Journal of Psychiatry
Manuscript ID	122026
Country	China

Category	Psychology
Manuscript Type	Retrospective Study
Article Title	Serum proprotein convertase subtilisin/kexin type 9 levels correlate with depression severity in post-stroke patients
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Yan Song, Yue Yang, Xiao-Yang Sun, Meng-Jun Zhang and Shu-Gen Wang
Funding Agency and Grant Number
Corresponding Author	Hong-Yan Song, Department of Pharmacy, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou 061000, Hebei Province, China. 963809412@qq.com
Key Words	Post-stroke depression; Evolocumab; Proprotein convertase subtilisin/kexin type 9; Statin; Depression scores; Biomarkers; Neuroinflammation
Core Tip	This study shows that evolocumab combined with statin therapy can significantly decrease serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels, and it has a positive effect on depression in patients with post-stroke depression. This displays a strong correlation (r = 0.652), indicating PCSK9 as a potential biomarker of depression severity. Combination therapy was superior, with a 73.4% response rate vs 48.4% monotherapy (P < 0.05), leading to reduced neuroinflammation and improved cognition. Our data support the use of PCSK9-targeted therapy as a novel adjunctive treatment strategy in post-stroke depression.
Citation	Song HY, Yang Y, Sun XY, Zhang MJ, Wang SG. Serum proprotein convertase subtilisin/kexin type 9 levels correlate with depression severity in post-stroke patients. World J Psychiatry 2026; In press

Received	2026-04-24 10:42
Peer-Review Started	2026-04-24 10:43
First Decision by Editorial Office Director	2026-05-20 08:28
Return for Revision	2026-05-20 08:28
Revised	2026-06-10 11:10
Publication Fee Transferred
Second Decision by Editor	2026-09-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-10 09:16
Articles in Press	2026-09-10 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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