Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	122057
DOI	10.4251/wjgo.122057
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Nuclear localization of proteasome subunit beta 5 serves as an independent prognostic biomarker and promotes invasion in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ai-Ping Xu, Shi-Pei She, Yi-Sheng Xiao, Jia Lang, Jing-Fang Yuan and Yuan-Feng Zeng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81960432 National Natural Science Foundation of China 82460599 Jiangxi Provincial Natural Science Foundation 20232BAB206091 Health Commission Science and Technology Program of Jiangxi Province 202410164
Corresponding Author	Yuan-Feng Zeng, Chief, Chief Physician, Director, Full Professor, PhD, Professor, Department of Pathology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 152 Aiguo Road, Donghu District, Nanchang 330006, Jiangxi Province, China. zyf760928@163.com
Key Words	Colorectal cancer; Proteasome subunit beta 5; Nuclear localization; Prognostic biomarker; Cell migration and invasion; Subcellular fractionation; Small interfering RNA knockdown
Core Tip	This is the first study to investigate the subcellular localization of proteasome subunit beta (PSMB) 5 in colorectal cancer (CRC). We demonstrate that nuclear PSMB5 Localization, rather than total PSMB5 expression, serves as an independent prognostic biomarker for poor overall survival in CRC patients. Functional assays show that PSMB5 silencing significantly impairs CRC cell invasion and migration. Notably, metastatic CRC cell lines exhibit higher nuclear-to-cytoplasmic PSMB5 ratios than non-metastatic counterparts. These findings establish nuclear-localized PSMB5 as a novel prognostic indicator and a potential therapeutic target in CRC.
Citation	Xu AP, She SP, Xiao YS, Lang J, Yuan JF, Zeng YF. Nuclear localization of proteasome subunit beta 5 serves as an independent prognostic biomarker and promotes invasion in colorectal cancer. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.122057
PDF	122057-in-press.pdf

Received	2026-04-09 02:53
Peer-Review Started	2026-04-09 02:55
First Decision by Editorial Office Director	2026-04-30 07:18
Return for Revision	2026-04-30 13:13
Revised	2026-05-16 05:44
Publication Fee Transferred	2026-05-25 04:55
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 07:30
Articles in Press	2026-06-22 07:30
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ISSN	1948-5204 (online)
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