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Articles in Press
11/2/2026 3:54:23 AM | Browse: 16 | Download: 2
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Transcriptomics reveals that Yang-Yin-He-Xue-Jie-Du formula promotes anal fistula healing by regulating tryptophan metabolism
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi Wang, A-Yue An, Yue-Ning Feng, Da-Yong Feng, Zhi-Yong Bai, Jing-Wen Wang and Chun-Hui Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Chun-Hui Wang, Department of Colorectal Surgery, WangJing Hospital of China Academy of Chinese Medical Sciences, No. 6 South Zhonghuan Road, Beijing 100102, China. jane_wang306@outlook.com |
| Key Words |
Yang-Yin-He-Xue-Jie-Du formula; Transcriptomics; Anal fistula; Tryptophan metabolism; Aldehyde oxidase 1 |
| Core Tip |
This study investigated the traditional Chinese medicine Yang-Yin-He-Xue-Jie-Du (YYHXJD) in a rat model of anal fistula and identified a high-dose 14-day regimen as the most effective within the 14-day observation period. Transcriptomic analysis suggested that YYHXJD may promote tissue repair by inducing aldehyde oxidase 1 to influence tryptophan metabolism, which is associated with reduced oxidative stress and inflammation while enhancing granulation tissue formation. However, metabolomic validation is required to confirm the proposed mechanism. |
| Citation |
Wang X, An AY, Feng YN, Feng DY, Bai ZY, Wang JW, Wang CH. Transcriptomics reveals that Yang-Yin-He-Xue-Jie-Du formula promotes anal fistula healing by regulating tryptophan metabolism. World J Gastrointest Surg 2026; In press
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| PDF |
122107-in-press.pdf
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Received |
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2026-05-15 10:21 |
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Peer-Review Started |
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2026-05-15 10:21 |
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First Decision by Editorial Office Director |
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2026-06-04 03:44 |
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Return for Revision |
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2026-06-04 03:44 |
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Revised |
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2026-06-17 07:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-11-02 02:19 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-02 03:54 |
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Articles in Press |
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2026-11-02 03:54 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
