| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Efficacy and safety of Huazhuojiedu decoction in the treatment of gastric precancerous lesions after endoscopic submucosal dissection
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying-Jie Si, Ning-Ning Ren, Jian-Yun Wang, Xin-Yu Hao, Zai-Jian Wang, Hui-Xia Li, Xue-Feng Ge, Jing An, Xiao-Shuang Shi, Tian Shen, Jie Liang, Xiao-Jing Ouyang, Xin-Yue Wang and Yan-Gang Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82575015 |
| Beijing Natural Science Foundation |
No. 7232281 |
| Beijing University of Chinese Medicine Project |
No. 2025-JYB-JBGS-001 |
| Beijing University of Chinese Medicine Third Affiliated Hospital New Drug Research and Development Projects |
No. 2025-YJKT-XYYF-02 |
|
| Corresponding Author |
Yan-Gang Wang, Department of Gastroenterology and Hepatology, Beijing University of Chinese Medicine Third Affiliated Hospital, 2nd Floor North Wing of the Ward Building, No. 51 Andingmenwai Xiaoguan Street, Chaoyang District, Beijing 100029, China. wangyangang1979@163.com |
| Key Words |
Huazhuojiedu decoction; Early gastric cancer; Endoscopic submucosal dissection; Gastric precancerous lesions; Integrated traditional and Western Medicine |
| Core Tip |
Huazhuojiedu decoction combined with conventional Western therapy significantly improves histopathological outcomes in patients with gastric precancerous lesions after endoscopic submucosal dissection. This study demonstrates enhanced reversal and improvement rates, better gastric function (pepsinogen I, the pepsinogen I/II ratio, gastrin-17), and reduced inflammatory cytokines (interleukin-6, interleukin-8, tumour necrosis factor-α). Importantly, the combination therapy is associated with a lower incidence of metachronous gastric cancer and reduced progression of precancerous lesions during follow-up. The findings suggest that Huazhuojiedu decoction may exert protective effects through anti-inflammatory and multi-target regulatory mechanisms, offering a promising integrative strategy for post-endoscopic submucosal dissection management, although further randomized controlled trials are required for confirmation. |
| Citation |
Si YJ, Ren NN, Wang JY, Hao XY, Wang ZJ, Li HX, Ge XF, An J, Shi XS, Shen T, Liang J, Ouyang XJ, Wang XY, Wang YG. Efficacy and safety of Huazhuojiedu decoction in the treatment of gastric precancerous lesions after endoscopic submucosal dissection. World J Gastrointest Surg 2026; In press
|
| PDF |
122120-in-press.pdf
|
