Publication Name	World Journal of Gastroenterology
Manuscript ID	122338
DOI	10.3748/wjg.122338
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Early chemotherapy after endoscopic retrograde cholangiopancreatography and survival in advanced pancreatic cancer with biliary obstruction
Manuscript Source	Unsolicited Manuscript
All Author List	Yun-Xiu Liao, Meng-Yu Cao, Yu-Fan Chen, Qing Yang, Shi-Yong Lin, Yin Li, Jun Weng, Xin-Xin Huang, Xiao-Yan Gao, Guo-Bao Wang, Jian-Jun Li and Hong-Bo Shan
Funding Agency and Grant Number	Funding Agency Grant Number Guangzhou Clinical Specialty Technology Construction Project No. 2026P-TS016
Corresponding Author	Hong-Bo Shan, Department of Endoscopy, Sun Yat-sen University Cancer Center, No. 651 Dongfengdong Street, Yuexiu District, Guangzhou 510060, Guangdong Province, China. shanhb@sysucc.org.cn
Key Words	Pancreatic ductal adenocarcinoma; Malignant distal biliary obstruction; Endoscopic retrograde cholangiopancreatography; Biliary drainage; Chemotherapy accessibility; Landmark analysis; Competing risk; Overall survival
Core Tip	This study reframed endoscopic biliary drainage in advanced pancreatic cancer as a bridge-to-chemotherapy intervention rather than a purely technical procedure. Using a 30-day landmark design with inverse probability weighting, early chemotherapy after drainage was associated with better survival. Baseline total bilirubin and early post-drainage bilirubin trajectory identified patients less likely to enter systemic therapy, supporting a pathway-oriented view of biliary drainage and early risk stratification after endoscopic intervention.
Citation	Liao YX, Cao MY, Chen YF, Yang Q, Lin SY, Li Y, Weng J, Huang XX, Gao XY, Wang GB, Li JJ, Shan HB. Early chemotherapy after endoscopic retrograde cholangiopancreatography and survival in advanced pancreatic cancer with biliary obstruction. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122338
PDF	122338-in-press.pdf

Received	2026-04-16 02:14
Peer-Review Started	2026-04-16 02:14
First Decision by Editorial Office Director	2026-04-29 10:17
Return for Revision	2026-04-29 10:17
Revised	2026-05-20 08:16
Publication Fee Transferred	2026-05-22 04:06
Second Decision by Editor	2026-06-22 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-06-22 06:58
Articles in Press	2026-06-22 06:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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