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Articles in Press
10/8/2026 9:23:48 AM | Browse: 17 | Download: 3
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Human umbilical cord mesenchymal stem cells repair islet structure and function in diabetic rats through metabolic reprogramming
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian Xu, Xia Yang, Hai-Yan Zhang, Li-Li Wang, Yuan-Dong Luo, Shuo-Liang Yang, Ya-Jing Zhou, Ying Liu and Xue-Feng Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hunan Provincial Natural Science Foundation |
2026JJ81776, 2026JJ80142, 2026JJ81116 |
| National Key Specialty Major Scientific Research Project of the Hunan Provincial Health Commission |
Z2023158 |
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| Corresponding Author |
Xue-Feng Yang, PhD, Professor, Department of Gastroenterology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, No. 336 Dongfeng South Road, Zhuhui District, Hengyang 421002, Hunan Province, China. yxf9988@126.com |
| Key Words |
Human umbilical cord mesenchymal stem cells; Diabetes mellitus; Sprague-Dawley; Islet function; Pancreatic metabolomics |
| Core Tip |
Diabetes mellitus (DM) is a prevalent metabolic disease. This study investigated the treatment efficacy of the human umbilical cord mesenchymal stem cells (hUC-MSCs) in repairing diabetic rat islets and the potential underlying mechanisms. Results showed that hUC-MSCs lowered blood glucose, improved insulin secretion and islet structure, and regulated pancreatic lipid and amino acid metabolism. Thirty key differential metabolites were identified as potential diagnostic and treatment efficacy prediction biomarkers. The results indicate that hUC-MSCs protects islets and improves glucose metabolism in DM by regulating pancreatic metabolism. |
| Citation |
Xu J, Yang X, Zhang HY, Wang LL, Luo YD, Yang SL, Zhou YJ, Liu Y, Yang XF. Human umbilical cord mesenchymal stem cells repair islet structure and function in diabetic rats through metabolic reprogramming. World J Stem Cells 2026; In press
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| PDF |
122760-in-press.pdf
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Received |
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2026-04-28 01:41 |
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Peer-Review Started |
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2026-04-28 01:41 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-06 07:20 |
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Revised |
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2026-07-27 02:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-09-09 06:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 09:23 |
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Articles in Press |
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2026-10-08 09:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
