Publication Name	World Journal of Hepatology
Manuscript ID	122845
DOI	10.4254/wjh.122845
Country	Türkiye

Category	Anesthesiology
Manuscript Type	Basic Study
Article Title	Effects of fullerenol C60 on hepatic ischemia-reperfusion injury in desflurane-anesthetized rats
Manuscript Source	Invited Manuscript
All Author List	Esat Kasapbasi, Cagri Ozdemir, Aydin Yavuz, Şaban Cem Sezen, Omer Kurtipek, Mustafa Kavutçu and Mustafa Arslan
Funding Agency and Grant Number
Corresponding Author	Cagri Ozdemir, Assistant Professor, Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Mehmet Akif Ersoy mahallesi, YDA Park Avenue Sitesi No:5 N Blok Kat 18 Daire 76, Ankara 06000, Türkiye. cagriozdemir@gazi.edu.tr
Key Words	Hepatic ischemia-reperfusion; Fullerenol C60; Desflurane; Oxidative stress; Liver injury
Core Tip	Hepatic ischemia-reperfusion injury (IRI) remains a major challenge during liver surgery and transplantation because oxidative stress and inflammation can cause significant tissue damage. This experimental study demonstrated that fullerenol C60 significantly reduced lipid peroxidation, preserved endogenous antioxidant enzyme activity, and improved histopathological liver injury in desflurane-anesthetized rats. Desflurane also provided partial protection, although the combined treatment showed no clear superiority over fullerenol alone. These findings suggest that fullerenol C60 may be a promising adjunctive strategy for limiting hepatic IRI and preserving liver function. Further translational and clinical studies are required to confirm optimal dosing, mechanisms, safety, and therapeutic applicability in humans.
Citation	Kasapbasi E, Ozdemir C, Yavuz A, Sezen SC, Kurtipek O, Kavutçu M, Arslan M. Effects of fullerenol C60 on hepatic ischemia-reperfusion injury in desflurane-anesthetized rats. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.122845
PDF	122845-in-press.pdf

Received	2026-04-29 03:32
Peer-Review Started	2026-04-29 03:33
First Decision by Editorial Office Director
Return for Revision	2026-06-24 06:29
Revised	2026-07-03 11:33
Publication Fee Transferred
Second Decision by Editor	2026-08-27 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 09:20
Articles in Press	2026-08-28 09:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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