Publication Name	World Journal of Gastroenterology
Manuscript ID	122956
DOI	10.3748/wjg.122956
Country	China

Category	Infectious Diseases
Manuscript Type	Observational Study
Article Title	Clonorchis sinensis co-infection potentiates polymorphonuclear-myeloid-derived suppressor cells expansion and metabolic reprogramming in chronic hepatitis B patients
Manuscript Source	Unsolicited Manuscript
All Author List	Jie-Ru Qiu, Hong-Bin Zhang, Mei Shang, Jue Xu, Yue-Chun Fu, Yuan Liao, Bo Hu and Hui-Min Dong
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 81902082
Corresponding Author	Hui-Min Dong, PhD, Researcher, Department of Laboratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou 510630, Guangdong Province, China. donghmin@mail.sysu.edu.cn
Key Words	Clonorchis sinensis; Chronic hepatitis B; Hepatitis B virus-Clonorchis sinensis co-infection; Polymorphonuclear myeloid-derived suppressor cell; Ornithine-to-arginine ratio; Immunosuppression
Core Tip	Compared with hepatitis B virus mono-infected patients with normal liver enzyme levels, Clonorchis sinensis co-infection expands polymorphonuclear-myeloid-derived suppressor cells. This activates the arginine (Arg)-ornithine (Orn) axis, raising the Orn-to-Arg ratio. Consequently, interferon-γ production is suppressed. The Orn-to-Arg ratio outperforms standard liver enzyme levels for immune assessment. Screening for Clonorchis sinensis is warranted even in patients with well-controlled viremia.
Citation	Qiu JR, Zhang HB, Shang M, Xu J, Fu YC, Liao Y, Hu B, Dong HM. Clonorchis sinensis co-infection potentiates polymorphonuclear-myeloid-derived suppressor cells expansion and metabolic reprogramming in chronic hepatitis B patients. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.122956
PDF	122956-in-press.pdf

Received	2026-05-07 02:14
Peer-Review Started	2026-05-07 02:17
First Decision by Editorial Office Director
Return for Revision	2026-07-21 02:15
Revised	2026-08-03 03:08
Publication Fee Transferred	2026-08-13 13:42
Second Decision by Editor	2026-09-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-10 09:18
Articles in Press	2026-09-10 09:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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