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Articles in Press
9/28/2026 9:28:48 AM | Browse: 18 | Download: 2
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanisms of Fuling Zexie decoction against metabolic dysfunction-associated steatotic liver disease: Integrative metabolomics, gut microbiota and serum pharmacochemistry
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Quan Wang, Huan Yang, Yan-Mei Tang, Yu-Xuan Tao, Shao-Cong Han, Qi-Di Zhou, Jie Yu and Xing-Xin Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82560801 |
| National Natural Science Foundation of China |
No. 82104381 |
| Yunnan Fundamental Research Projects |
No. 202505AF350032 |
| Yunnan Fundamental Research Projects |
No. 202407AB110018 |
| Yunnan Fundamental Research Projects |
No. 202201AW070016 |
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| Corresponding Author |
Xing-Xin Yang, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, No. 1076 Yuhua Road, Kunming 650500, Yunnan Province, China. yxx78945@163.com |
| Key Words |
Active components; Fuling Zexie decoction; Intestinal microbiota; Metabolic dysfunction-associated steatotic liver disease; Metabolites |
| Core Tip |
This study employed an integrative strategy combining metabolomics, gut microbiome profiling, and serum pharmacochemical analysis to elucidate the therapeutic effects of Fuling Zexie decoction on metabolic dysfunction associated with steatotic liver disease. Fuling Zexie decoction normalized 226 metabolites and 17 pathways in rats, while also reducing the Firmicutes/Bacteroidota ratio and the abundance of three pathogenic bacteria. Among 39 serum-derived components, 24 key ones regulated 17 targets, 10 pathways, and 18 metabolites, and downregulated nitric oxide synthase 2, monoamine oxidase A, and macrophage migration inhibitory factor to alleviate hepatic steatosis. |
| Citation |
Wang PQ, Yang H, Tang YM, Tao YX, Han SC, Zhou QD, Yu J, Yang XX. Mechanisms of Fuling Zexie decoction against metabolic dysfunction-associated steatotic liver disease: Integrative metabolomics, gut microbiota and serum pharmacochemistry. World J Gastroenterol 2026; In press
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| PDF |
123034-in-press.pdf
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Received |
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2026-05-07 09:25 |
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Peer-Review Started |
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2026-05-07 09:25 |
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First Decision by Editorial Office Director |
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2026-06-10 08:51 |
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Return for Revision |
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2026-06-10 08:51 |
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Revised |
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2026-06-23 23:49 |
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Publication Fee Transferred |
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2026-07-02 02:25 |
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Second Decision by Editor |
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2026-09-28 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-28 09:28 |
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Articles in Press |
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2026-09-28 09:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
