Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	123043
DOI	10.4251/wjgo.123043
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Preoperative gut dysbiosis and its correlation with postoperative infectious complications and tumor recurrence in colorectal cancer patients
Manuscript Source	Unsolicited Manuscript
All Author List	Rui Luo, Hai-Fen Ji and Lin-Ding Wang
Funding Agency and Grant Number
Corresponding Author	Lin-Ding Wang, Department of Microbiology, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei 230032, Anhui Province, China. 2035010018@stu.ahmu.edu.cn
Key Words	Colorectal cancer; Gut dysbiosis; Infective complications; Tumor recurrence; 16S rRNA sequencing; Perioperative management
Core Tip	Preoperative gut dysbiosis, defined by Shannon diversity index < 3.0 or Dysbiosis Index (DI) ≥ 2, was identified in 61.8% of colorectal cancer (CRC) patients undergoing curative resection. Dysbiosis independently predicted 30-day postoperative infectious complications (odds ratio = 2.85) and 2-year tumor recurrence (hazard ratio = 2.42) after multivariable adjustment. A combined biomarker model integrating the DI, C-reactive protein, and procalcitonin achieved area under the curve = 0.82 for infectious complication prediction. These findings support routine preoperative gut microbiome assessment as a clinically actionable risk stratification tool in perioperative CRC management.
Citation	Luo R, Ji HF, Wang LD. Preoperative gut dysbiosis and its correlation with postoperative infectious complications and tumor recurrence in colorectal cancer patients. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.123043
PDF	123043-in-press.pdf

Received	2026-06-10 11:06
Peer-Review Started	2026-06-10 11:06
First Decision by Editorial Office Director
Return for Revision	2026-07-01 02:22
Revised	2026-07-24 04:03
Publication Fee Transferred	2026-08-01 04:30
Second Decision by Editor	2026-10-28 07:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 10:21
Articles in Press	2026-10-28 10:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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