Publication Name	World Journal of Gastroenterology
Manuscript ID	123195
DOI	10.3748/wjg.123195
Country	China

Category	Computer Science, Artificial Intelligence
Manuscript Type	Retrospective Study
Article Title	Integrating immune-inflammatory and nutritional indicators into machine learning-driven risk stratification for colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Lang Wang, Chang Liu, Jian Xie, Jin-Shan Liu, Xiong Zhou, Fei Liu, Chen-Yu Xiang, Jun-Nan Zhao, Xu-Rui Liu, Xiao-Yu Liu, Bing Kang, Yong Cheng and Dong Peng
Funding Agency and Grant Number	Funding Agency Grant Number CQMU Program for Youth Innovation in Future Medicine No. W0190 Natural Science Foundation of Chongqing, China No. CSTB2024NSCQ-MSX0098
Corresponding Author	Dong Peng, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China. carry_dong@hospital.cqmu.edu.cn
Key Words	Colorectal cancer; Immune-inflammatory and nutritional indicators; Metabolic; Post-operative complications; Overall survival; Machine learning
Core Tip	This multicenter cohort study included 10205 patients with colorectal cancer (CRC) who underwent radical surgery. We systematically evaluated systemic inflammation- and nutrition-related indicators in relation to postoperative complications and overall survival, and further assessed metabolic dysfunction indices in a sub-cohort. Machine learning models were developed and externally validated, with gradient boosting survival analysis showing stable performance across centers. These findings support the integration of inflammatory, nutritional, and metabolic indicators into individualized risk stratification for CRC.
Citation	Wang L, Liu C, Xie J, Liu JS, Zhou X, Liu F, Xiang CY, Zhao JN, Liu XR, Liu XY, Kang B, Cheng Y, Peng D. Integrating immune-inflammatory and nutritional indicators into machine learning-driven risk stratification for colorectal cancer. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123195
PDF	123195-in-press.pdf

Received	2026-05-12 05:56
Peer-Review Started	2026-05-12 05:57
First Decision by Editorial Office Director	2026-06-05 08:55
Return for Revision	2026-06-05 08:55
Revised	2026-06-27 18:50
Publication Fee Transferred	2026-07-20 07:26
Second Decision by Editor	2026-08-13 02:29
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-14 09:21
Articles in Press	2026-08-14 09:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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