Publication Name	World Journal of Clinical Oncology
Manuscript ID	123328
DOI	10.5306/wjco.123328
Country	India

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Genomic landscape and clinical actionability of renal cell carcinoma in an Indian cohort: A real-world targeted next-generation sequencing study
Manuscript Source	Unsolicited Manuscript
All Author List	Vineet Talwar, Arpit Jain, Varun Goel, Bhumi Agarwal, Prateek Gupta, Rupal Tripathi, Sudhir Rawal and Anurag Mehta
Funding Agency and Grant Number
Corresponding Author	Arpit Jain, Consultant, Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector -5, Rohini, New Delhi 110085, India. jain.arpit@rgcirc.org
Key Words	Clear cell renal cell carcinoma; Next-generation sequencing; Precision oncology; Real-world data; European Society for Medical Oncology Scale for Clinical Actionability of Molecular Targets
Core Tip	Renal cell carcinoma (RCC) demonstrates significant molecular heterogeneity; however, genomic data from Indian patients remain limited. In this real-world single-center study, targeted next-generation sequencing identified recurrent alterations in VHL, PBRM1, SETD2, ATM, and TP53, with concurrent VHL-PBRM1 mutations representing the most frequent co-alteration pattern. Potentially actionable alterations, primarily involving the PI3K-AKT-mTOR pathway, were detected in a subset of patients based on the European Society for Medical Oncology Scale for Clinical Actionability of Molecular Targets. These findings provide important insights into the genomic profile and therapeutic implications of RCC in an underrepresented population.
Citation	Talwar V, Jain A, Goel V, Agarwal B, Gupta P, Tripathi R, Rawal S, Mehta A. Genomic landscape and clinical actionability of renal cell carcinoma in an Indian cohort: A real-world targeted next-generation sequencing study. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.123328
PDF	123328-in-press.pdf

Received	2026-05-20 07:37
Peer-Review Started	2026-05-20 07:37
First Decision by Editorial Office Director
Return for Revision	2026-07-10 03:16
Revised	2026-07-15 10:32
Publication Fee Transferred	2026-07-28 01:41
Second Decision by Editor	2026-08-13 02:29
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-14 09:33
Articles in Press	2026-08-14 09:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com