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Articles in Press
9/8/2026 9:36:56 AM | Browse: 23 | Download: 2
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Identification of region-specific signaling modules governing Crohn’s pathogenesis via mass spectrometry-based integrative acetyl-proteomics
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ya-Jing Guo, Jing Wen, Jing-Xia Liu, Yi-Ning Gao and Xing-Wang Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82405585 |
| Henan Province Science and Technology Research Project |
No. 252102311264 |
| Henan Higher Education Key Research Project |
No. 23A360019 |
| China Postdoctoral Science Foundation |
No. 2025M773941 |
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| Corresponding Author |
Xing-Wang Chen, Director, Head, PhD, Professor, School of Acupuncture-Moxibustion and Tuina, Henan University of Chinese Medicine, No. 156 Jinshui East Road, Zhengdong New District, Zhengzhou 450046, Henan Province, China. 787746907@qq.com |
| Key Words |
Crohn’s disease; Lysine acetylation; Proteomics; Histone modification; Regional heterogeneity; Gut microbiota; Nuclear factor kappa-B signaling; 2,4,6-trinitrobenzenesulfonic acid-induced colitis |
| Core Tip |
This study presents a segment-resolved acetyl-proteomic landscape in a rat model of Crohn’s disease, revealing distinct acetylation signatures across the proximal, mid, and distal colon. Fifteen hub proteins, including receptor-interacting serine/threonine-protein kinase 2, signal transducer and activator of transcription 1, nuclear factor kappa B subunit 2, Ywhaz and SMRD2 were identified from the acetyl-protein interaction network. Site-specific validation by parallel reaction monitoring confirmed the reliability of the discovery proteomics. These region-specific acetylation patterns and hub proteins provide a foundation for biomarker discovery and targeted therapeutic strategies in Crohn’s disease. |
| Citation |
Guo YJ, Wen J, Liu JX, Gao YN, Chen XW. Identification of region-specific signaling modules governing Crohn’s pathogenesis via mass spectrometry-based integrative acetyl-proteomics. World J Gastroenterol 2026; In press
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| PDF |
123358-in-press.pdf
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Received |
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2026-05-25 07:18 |
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Peer-Review Started |
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2026-05-25 07:18 |
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First Decision by Editorial Office Director |
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2026-06-12 09:25 |
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Return for Revision |
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2026-06-23 07:09 |
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Revised |
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2026-07-24 13:02 |
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Publication Fee Transferred |
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2026-08-12 04:07 |
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Second Decision by Editor |
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2026-09-08 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-08 09:36 |
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Articles in Press |
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2026-09-08 09:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
