Publication Name	World Journal of Gastroenterology
Manuscript ID	123374
DOI	10.3748/wjg.123374
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Kai Liu, Xiao-Han Zhang, Xiang-Yu Zhou, Yu-Xuan Liu, Shi-Qi Pan, Ting-Xiu Liu, Robb Russell, Xue-Hui Wang, Yu-Pu Yao, Xing-Jie Zhao, Hui-Yi Sun, Chuan-Lan Ju, Jian-Ping Liu and Zhao-Lan Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82374298
Corresponding Author	Zhao-Lan Liu, PhD, Professor, Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, No. 11 East Road of North Third Ring Road, Chaoyang District, Beijing 100029, China. lzl1019@163.com
Key Words	Ulcerative colitis; Meta-analysis; Clinical features; Biomarkers; Association strengths
Core Tip	This systematic meta-analysis quantifies the associations of non-invasive clinical features and laboratory biomarkers with ulcerative colitis (UC). Based on 389 studies, bloody mucopurulent stools and tenesmus are strongly associated with UC, while perianal fistulae and abdominal masses link more directly to Crohn’s disease. Furthermore, fecal calprotectin, erythrocyte sedimentation rate, and C-reactive protein show significant associations with UC activity and differential risks. Mapping these clinical and biomarker associations offers an evidence-based framework to optimize patient prioritization for invasive endoscopy.
Citation	Liu K, Zhang XH, Zhou XY, Liu YX, Pan SQ, Liu TX, Russell R, Wang XH, Yao YP, Zhao XJ, Sun HY, Ju CL, Liu JP, Liu ZL. Clinical features and biomarkers associated with ulcerative colitis: A systematic review and meta-analysis. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123374
PDF	123374-in-press.pdf

Received	2026-05-18 08:10
Peer-Review Started	2026-05-18 08:10
First Decision by Editorial Office Director
Return for Revision	2026-07-07 07:54
Revised	2026-07-19 10:26
Publication Fee Transferred	2026-08-06 09:57
Second Decision by Editor	2026-09-02 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-04 09:16
Articles in Press	2026-09-04 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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