Publication Name	World Journal of Gastroenterology
Manuscript ID	123418
DOI	10.3748/wjg.123418
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Long-term treatment trajectories and surgical outcomes in Chinese patients with ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Jing Yang, Ling-Ya Yao, Yu-Shu Cao, Wen-Hao Xia, Xiang-Han Cao, Yi-Ning Xu, You-Jie Miao and Qian Cao
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program of China 2023YFC2507300 National Natural Science Foundation of China 82341215, 82370531 Key-Area Research and Development Program of Guangdong Province 2023B1111040003
Corresponding Author	Qian Cao, MD, PhD, Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. caoq@zju.edu.cn
Key Words	Ulcerative colitis; Disease activity; Natural history; Treatment; Chinese cohort; Treat-to-target strategies
Core Tip	In this large real-world cohort of 1882 Chinese patients with ulcerative colitis (UC) followed for a median of over six years, baseline disease activity was a major determinant of treatment escalation and colectomy risk. Although most patients with mild-to-moderate disease achieved sustained control with 5-aminosalicylates, important gaps in treat-to-target care remained, including infrequent early endoscopic reassessment and delayed treatment optimization among non-responders. These findings highlight the need for timely disease monitoring and severity-stratified management to improve long-term outcomes in UC.
Citation	Yang WJ, Yao LY, Cao YS, Xia WH, Cao XH, Xu YN, Miao YJ, Cao Q. Long-term treatment trajectories and surgical outcomes in Chinese patients with ulcerative colitis. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.123418
PDF	123418-in-press.pdf

Received	2026-05-18 09:14
Peer-Review Started	2026-05-18 09:15
First Decision by Editorial Office Director	2026-06-01 07:37
Return for Revision	2026-06-01 07:37
Revised	2026-06-13 06:08
Publication Fee Transferred	2026-07-08 11:56
Second Decision by Editor	2026-07-16 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-16 06:53
Articles in Press	2026-07-16 06:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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